Lab achievements

Publications

2022

Dobashi K, Katagiri A, Fujii N, Nishiyasu T. Combined Effects of Hypocapnic Hyperventilation and Hypoxia on Exercise Performance and Metabolic Responses During the Wingate Anaerobic Test. Int J Sports Physiol Perform. 2022 Dec 15;18(1):69-76.

Fujii N, Kataoka Y, Lai YF, Shirai N, Hashimoto H, Nishiyasu T. Ingestion of carbonated water increases middle cerebral artery blood velocity and improves mood states in resting humans exposed to ambient heat stress. Physiol Behav. ahead of print. 2022

Zheng H, Badenhorst CE, Lei TH, Che Muhamed AM, Liao YH, Fujii N, Kondo N, Mündel T. Do E 2 and P 4 contribute to the explained variance in core temperature response for trained women during exertional heat stress when metabolic rates are very high? Eur J Appl Physiol. ahead of print. 2022

Fujii N, Amano T, Kenny GP, Mündel T, Lei TH, Honda Y, Kondo N, Nishiyasu T. TMEM16A blockers T16Ainh-A01 and benzbromarone do not modulate the regulation of sweating and cutaneous vasodilatation in humans in vivo. Exp Physiol. 107(8):844-853. 2022

Cao Y, Fujii N, Fujimoto T, Lai YF, Ogawa T, Hiroyama T, Enomoto Y, Nishiyasu T. CO 2-Enriched Air Inhalation Modulates the Ventilatory and Metabolic Responses of Endurance Runners During Incremental Running Under Hypobaric Hypoxia. High Alt Med Biol. 23(2):125-134. 2022

Fujii N, Meade RD, Schmidt MD, King KE, Boulay P, Ruzicka M, Amano T, Kenny GP. The effect of acute intradermal administration of ascorbate on heat loss responses in older adults with uncomplicated controlled hypertension. Exp Physiol. 107(8):834-843. 2022

Moriyama S, Ichinose M, Dobashi K, Matsutake R, Sakamoto M, Fujii N, Nishiyasu T. Hypercapnia elicits differential vascular and blood flow responses in the cerebral circulation and active skeletal muscles in exercising humans. Physiol Rep. 10(8):e15274. 2022

Amano T, Fujii N, Kenny GP, Okamoto Y, Inoue Y, Kondo N. Effects of tetraethylammonium-sensitive K + channel blockade on cholinergic and thermal sweating in endurance-trained and untrained men. Exp Physiol. 107(5):441-449. 2022

King KE, McCormick JJ, Notley SR, Fujii N, Kenny GP. Serum klotho concentrations in young and older men during prolonged exercise in temperate and hot conditions. Curr Aging Sci. 15(2):180-185. 2022

Amano T, Watanabe D, Otsuka J, Okamoto Y, Takada S, Fujii N, Kenny GP, Enoki Y, Maejima D. Comparison of hydration efficacy of carbohydrate-electrolytes beverages consisting of isomaltulose and sucrose in healthy young adults: A randomized crossover trial. Physiol Behav. 15;249:113770. 2022

McCormick JJ, King KE, Notley SR, Fujii N, Boulay P, Sigal RJ, Kenny GP. Exercise in the heat induces similar elevations in serum irisin in young and older men despite lower resting irisin concentrations in older adults. J Therm Biol. 104:103189. 2022

McGarr GW, King KE, Akerman AP, Fujii N, Ruzicka M, Kenny GP. Influence of uncomplicated, controlled hypertension on local heat-induced vasodilation in nonglabrous skin across the body. Am J Physiol Regul Integr Comp Physiol. 1;322(4):R326-R335. 2022

Fujii N, McGarr GW, Amano T, Boulay P, Nishiyasu T, Kenny GP. Does aging alter skin vascular function in humans when spatial variation is considered? Microcirculation. 29(2):e12743. 2022

Kataoka Y, Kenny G, Nishiyasu T, Amano T, Mundel T, Zheng H, Lei TH, Watanabe K, Fujii N. TRPA1 channel activation with cinnamaldehyde induces cutaneous vasodilation through NOS, but not COX and KCa channel, mechanisms in humans. J Cardio Pharmacol. 1;79(3):375-382, 2022

2021

Tanabe Y, Fujii N, Suzuki K. Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans Nutrients. 24;14(1):70. 2021

Zheng H, Badenhorst CE, Lei TH, Che Muhamed AM, Liao YH, Amano T, Fujii N, Nishiyasu T, Kondo N, Mundel T. Measurement error of self-paced exercise performance in athletic women is not affected by ovulatory status or ambient environment. J Appl Physiol. 131(5):1496-1504, 2021

Katagiri A, Kitadai Y, Miura A, Fukuba Y, Fujii N, Nishiyasu T, Tsuji B. Sodium bicarbonate ingestion mitigates the heat-induced hyperventilation and reduction in cerebral blood velocity during exercise in the heat. J Appl Physiol. 131(5):1617-1628, 2021

Fujii N, Kenny GP, Amano T, Honda Y, Kondo N, Nishiyasu T. Na+/K+-ATPase plays a major role in mediating cutaneous thermal hyperemia achieved by local skin heating to 39℃. J Appl Physiol. 131(5):1408-1416, 2021

Fujii N, Sugihara A, Watanabe K, Niwa T, Katagiri A, Moriyama S, Miyanagi I, Kojima J, Nishiyasu T. Carbohydrate hastens hypervolemia achieved through ingestion of aqueous sodium solution in resting euhydrated humans. Eur J Appl Physiol. 121(12):3527-3537, 2021

Fujii N, Fujisawa K, Dobashi K, Cao Y, Matsutake R, Lai, YF, Nishiyasu T. Effects of High-intensity Exercise Repetition Number during Warm-up on Physiological Responses, Perceptions, Readiness, and Performance. Res Q Exerc Sport. ahead of print, 2021

Fujimoto T, Fujii N, Dobashi K, Cao Y, Matsutake R, Takayanagi M, Kondo N, Nishiyasu T. Effects of low-intensity exercise on local skin and whole-body thermal sensation in hypothermic young males. Physiol Behav. 240:113531, 2021

McGarr GW, King KE, Saci S, Leduc D, Akerman AP, Fujii N, Kenny GP. Regional variation in nitric oxide-dependent cutaneous vasodilatation during local heating in young adults. Exp Physiol. 106(8):1671-1678, 2021

Amano T, Katayama S, Okamoto Y, Otsuka J, Fujii N, Kenny GP, Nishiyasu T, Enoki Y, Maejima D. Comparisons of isomaltulose, sucrose, and mixture of glucose and fructose ingestions on postexercise hydration state in young men. Eur J Nutr. 60(8):4519-4529, 2021

Fujii N, McGarr GW, Amano T, Nishiyasu T, Sigal RJ, Kenny GP. Type 2 diabetes impairs vascular responsiveness to nitric oxide, but not the venoarteriolar reflex or post-occlusive reactive hyperaemia in forearm skin. Exp Dermatol. 30(12)1807-1813, 2021

Lei TH, Fujiwara M, Gerrett N, Amano T, Mundel T, Inouc Y, Okushima D, Nishiyasu T, Kondo N. The effect of seasonal acclimatization on whole-body heat loss response during exercise in a hot humid environment with different air velocity. J Appl Physiol. 131(2):520-531, 2021

Otsuka J, Okamoto Y, Fujii N, Enoki Y, Maejima D, Nishiyasu T, Amano T. Effects of Isomaltulose Ingestion on Thermoregulatory Responses during Exercise in a Hot Environment. Int J Environ Res Public Health. 18(11):5760, 2021

Tanabe Y, Akazawa N, Nishimaki M, Shimizu K, Fujii N, Takahashi H. Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate Ingestion on Muscle Damage after Eccentric Exercise in Healthy Males: A Pilot Placebo-Controlled Double-Blind Crossover Study. J Diet Suppl. ahead of print, 2021

Zheng H, Badenhorst CE, Lei TH, Liao YH, Che Muhamed AM, Fujii N, Kondo N, Mündel T. Menstrual phase and ambient temperature do not influence iron regulation in the acute exercise period. Am J Physiol Regul Integr Comp Physiol. 320(6):R780-R790, 2021

Tanabe Y, Shimizu K, Sagayama H, Fujii N, Takahashi H. Urinary N-terminal fragment of titin: A surrogate marker of serum creatine kinase activity after exercise-induced severe muscle damage. J Sports Sci. 39(13):1437-1444, 2021

Arnold JT, Bailey SJ, Hodder SG, Fujii N, Lloyd AB. Independent and combined impact of hypoxia and acute inorganic nitrate ingestion on thermoregulatory responses to the cold. Eur J Appl Physiol. 121:1207-1218, 2021

Fujii N, Kenny GP, McGarr GW, Amano T, Honda Y, Kondo N, Nishiyasu T. TRPV4 channel blockade does not modulate skin vasodilation and sweating during hyperthermia or cutaneous post-occlusive reactive and thermal hyperemia. Am J Physiol Regul Integr Comp Physiol. 320:R563-R573, 2021

Fujii N, Fujimoto T, Cao Y, Dobashi K, Matsutake R, Amano T, Wanatabe K, Nishiyasu T. Caffeine Exacerbates Hyperventilation and Reductions in Cerebral Blood Flow in Physically Fit Males Exercising in the Heat. Med Sci Sports Exerc. 53(4):845-852, 2021

Fujii N, McGarr GW, Notley SR, Boulay P, Sigal RJ, Amano T, Nishiyasu T, Poirier MP, Kenny GP. Effects of short-term heat acclimation on whole-body heat exchange and local nitric oxide synthase- and cyclooxygenase-dependent heat loss responses in exercising older men. Exp Physiol. 106(2):450-462, 2021

Tanabe Y, Nakata Y, Zempo-Miyaki A, Hieda MY, Choi Y, Fujii N, Maeda S. Different degree of intervention in 6-month weight-loss support and arterial stiffness: Secondary analysis of a randomized controlled trial. Obes Res Clin Pract. 15(1):93-95, 2021

McGarr GW, Muia CM, Saci S, Fujii N, Kenny GP. KCa channels are major contributors to ATP-induced cutaneous vasodilation in healthy older adults. Microvasc Res. 133:104096, 2021

2020

Amano T, Fujii N, Kenny GP, Nishiyasu T, Inoue Y, Kondo N. The relative contribution of α- and β-adrenergic sweating during heat exposure and the influence of sex and training status. Exp Dermatol. 29(12):1216-1224, 2020

Amano T, Fujii N, Kenny GP, Okamoto Y, Inoue Y, Kondo N. Effects of L-type voltage-gated Ca 2+ channel blockade on cholinergic and thermal sweating in habitually trained and untrained men. Am J Physiol Regul Integr Comp Physiol. 319(5):R584-R591, 2020

McGarr GW, Fujii N, Schmidt MD, Muia CM, Kenny GP. Heat shock protein 90 modulates cutaneous vasodilation during an exercise-heat stress, but not during passive whole-body heating in young women. Physiol Rep. 8(16):e14552, 2020

Amano T, Sekihara S, Fujii N, Kenny GP, Inoue Y, Kondo N. Does the iontophoretic application of bretylium tosylate modulate sweating during exercise in the heat in habitually trained and untrained men? Exp Physiol. 105(10):1692-1699, 2020

McCormick JJ, King KE, Côté MD, McManus MK, Topshee SM, Hsu HS, Fujii N, Kenny GP. Regulation of autophagy following ex vivo heating in peripheral blood mononuclear cells from young adults. J Therm Biol. 91:102643, 2020

Arnold JT, Lloyd AB, Bailey SJ, Fujimoto T, Matsutake R, Takayanagi M, Nishiyasu T, Fujii N. The nitric oxide dependence of cutaneous microvascular function to independent and combined hypoxic cold exposure. J Appl Physiol. 129(4):947-956, 2020

Dobashi K, Fujii N, Ichinose M, Fujimoto T, Nishiyasu T. Volunatry hypocapnic hyperventilation lasting 5 and 20 min similarly reduce aerobic metabolism without affecting power outputs during Wingate anaerobic test. Eur J Sport Sci. 17:1-8, 2020

Fujii N, McGarr GW, Amano T, Sigal RJ, Boulay P, Nishiyasu T, Kenny GP. Ageing augments β‐adrenergic cutaneous vasodilatation differently in men and women with no effect on β‐adrenergic sweating. Exp Physiol. 105(10):1720-1729, 2020

Fujii N, McGarr GW, Ghassa R, Schmidt MD, McCormick JJ, Nishiyasu T, Kenny GP. Sex-differences in Cholinergic, Nicotinic, and β-adrenergic Cutaneous Vasodilation: Roles of Nitric Oxide Synthase, Cyclooxygenase, and K + Channels. Microvasc Res. 131:104030, 2020

Schmidt MD, McGarr GW, Muia CM, Fujii N, Amano T, Kenny GP. Regional Influence of Nitric Oxide on Cutaneous Vasodilatation and Sweating During Exercise-Heat Stress in Young Men. Exp Physiol. 105(5):773-782, 2020

Ogawa T, Nagao M,Fujii N, Nishiyasu T. Effect of inspiratory muscle-loaded exercise training on peak oxygen uptake and ventilatory response during incremental exercise under normoxia and hypoxia. BMC Sports Sci Med Rehabil. 15;12:25, 2020

Amano T,Fujii N, Kenny GP, Inoue Y, Kondo N. Does α 1-adrenergic Receptor Blockade Modulate Sweating During Incremental Exercise in Young Endurance-Trained Men? Eur J Appl Physiol. 120(5):1123-1129, 2020

Fujii N, McGarr GW, Kenny GP, Amano T, Honda Y, Kondo N, Nishiyasu T. NO mediated activation of KATP channels contributes to cutaneous thermal hyperaemia in young adults. Am J Physiol Regul Integr Comp Physiol. 318(2):R390-R398, 2020

McGarr GW, Ghassa R, Fujii N, Amano T, Kenny GP. Exp Physiol. Regional contributions of nitric oxide synthase to cholinergic cutaneous vasodilatation and sweating in young men. Exp Physiol. 105(2):236-243, 2020

McGarr GW, Fujii N, Muia CM, Nishiyasu T, Kenny GP. Intradermal Administration of Atrial Natriuretic Peptide Attenuates Cutaneous Vasodilation but Not Sweating in Young Men during Exercise in the Heat. Skin Pharmacol Physiol. 31:1-8, 2020

Fujii N, McGarr GW, McNeely BD, Ichinose M, Nishiyasu T, Kenny GP. KCa and KV channels modulate the venoarteriolar reflex in non-glabrous human skin with no roles of KATP channels, NOS, and COX. Eur J Pharmacol. 5;866:172828, 2020

Fujii N, McGarr GW, Ichinose M, Nishiyasu T, Kenny GP. Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperemia in non-glabrous human skin with no roles of NOS and COX. Microcirculation. 27(1):e12586, 2020

2019

Muia CM, McGarr GW, Schmidt MD, Fujii N, Amano T, Kenny GP. Contribution of nitric oxide synthase to cutaneous vasodilatation and sweating in men of black-African and Caucasian descent during exercise in the heat. Exp Physiol. 104(12):1762-1768, 2019

Fujii N, Amano T, Kenny GP, Honda Y, Kondo N, Nishiyasu T. Nicotinic receptors modulate skin perfusion during normothermia, and have a limited role in skin vasodilatation and sweating during hyperthermia. Exp Physiol. 104(12):1808-1818, 2019

Fujii N, McGarr GW, Sigal RJ, Boulay P, Nishiyasu T, Kenny GP. Ageing augments nicotinic and adenosine triphosphate-induced, but not muscarinic, cutaneous vasodilatation in women. Exp Physiol. 104(12):1801-1807, 2019

Notley SR, Poirier MP, Sigal RJ, D’Souza A, Flouris AD,Fujii N, Kenny GP. Exercise Heat Stress in Patients With and Without Type 2 Diabetes. JAMA. Oct 8;322(14):1409-1411, 2019

Amano T, Sugiyama Y, Okumura J, Fujii N, Kenny GP, Nishiyasu T, Inoue Y, Kondo N, Sasagawa K, Enoki Y, Maejima D. Effects of isomaltulose ingestion on postexercise hydration state and heat loss responses in young men. Exp Physiol. 104(10):1494-1504, 2019.

Fujii N, Hatam K, McGarr GW, Meade RD, Boulay P, Nishiyasu T, Kenny GP. Exogenous Activation of Protease-Activated Receptor 2 Attenuates Cutaneous Vasodilatation and Sweating in Older Men Exercising in the Heat. Skin Pharmacol Physiol. 32(5):235-243, 2019

Fujii N, Kenny GP, Amano T, Honda Y, Kondo N, Nishiyasu T. Evidence for TRPV4 channel induced skin vasodilatation through NOS, COX, and KCa channel mechanisms with no effect on sweat rate in humans. Eur J Pharmacol. 5;858:172462, 2019.

McGarr GW, Fujii N, McNeely BD, Hatam K, Nishiyasu T, Sigal RJ, Boulay P, Kenny GP. Superoxide and NADPH oxidase do not modulate skin blood flow in older exercising adults with and without type 2 dia-betes. Microvasc Res. 25:103886, 2019

Fujii N, McGarr GW, Hatamu K, Chandran N, Muia CM, Nishiyasu T, Boulay P, Ghassa R, Kenny GP. Heat shock protein 90 does not contribute to cutaneous vasodilatation in older adults during heat stress Microcirculation. 4:e12541, 2019

McGarr GW,Fujii N, Muia CM, Nishiyasu T, Kenny GP. Separate and combined effects of KCa and KATP channel blockade with NOS inhibition on cutaneous vasodilation and sweating in older men during heat stress. Am J Physiol Regul Integr Comp Physiol. Jul 1;317(1):R113-R120, 2019

Fujimoto T, Tsuji B, Sasaki Y, Dobashi K, Sengoku Y,Fujii N, Nishiyasu T. Low-intensity exercise delays the shivering response to core cooling. Am J Physiol Regul Integr Comp Physiol. 316(5):R535-R542, 2019

Ogawa T, Fujii N, Kurimoto Y, Nishiyasu T. Effect of hypobaria on maximal ventilation, oxygen uptake, and exercise performance during running under hypobaric normoxic conditions. Physiol Rep. Feb;7(3):e14002, 2019

Cao Y, Ichikawa Y, Sasaki Y, Ogawa T, Hiroyama T, Enomoto Y, Fujii N, Nishiyasu T. Expiratory flow limitation under moderate hypobaric hypoxia does not influence ventilatory responses during incremental running in endurance runners. Physiol Rep. (3):e13996, 2019

Meade RD,Fujii N, McGarr GW, Alexander LM, Boulay P, Sigal RJ, Kenny GP. Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise. J Appl Physiol. (1985), 126(4):1129-1137, 2019

Tsuji B, Hoshi Y, Honda Y, Fujii N, Sasaki Y, Cheung SS, Kondo N, Nishiyasu T. Respiratory mechanics and cerebral blood flow during heat-induced hyperventilation and its voluntary suppression in passively heated humans. Physiol Rep. 7(1):e13967, 2019

Fujii N, McGarr GW, Nishiyasu T, Sigal RJ, Boulay P, Kenny GP. Ageing attenuates muscarinic-mediated sweating differently in men and women with no effect on nicotinic-mediated sweating. Exp Dermatol. 28(8):968-971, 2019

Fujii N, Kashihara M, Kenny GP, Honda Y, Fujimoto T, Cao Y, Nishiyasu T. Carotid chemoreceptors have a limited role in mediating the hyperthermia-induced hyperventilation in exercising humans. J Appl Physiol. 126(2):305-313, 2019

2018

Fujii N, Pastore OL, McGarr GW, Meade RD, McNeely BD, Nishiyasu T, Kenny GP. Cyclooxygenase-1 and -2 modulate sweating but not cutaneous vasodilation during exercise in the heat in young men. Physiol Rep. 6(17):e13844, 2018

Fujii N, Hara H, Enomoto Y, Tanigawa S, and Nishiyasu T. Effects of work-matched supramaximal intermittent vs. submaximal constant-workload warm-up on all-out effort power output at the end of 2 minutes of maximal cycling. Eur J Sport Sci. 19(3):336-344, 2019

Amano T,Fujii N, Inoue Y, Kondo N. Cutaneous adrenergic nerve blockade attenuates sweating during incremental exercise in habitually trained men. J Appl Physiol. 1;125(4):1041-1050. 2018

Fujii N, Danquah MO, Meade RD, Nishiyasu T, and Kenny GP. The effect of exogenous activation of protease-activated receptor 2 on cutaneous vasodilatation and sweating in young males during rest and exercise in the heat. Temperature. 5(3):257-266, 2018

Fujii N, Nishiyasu T, Sigal RJ, Boulay P, McGarr GW, Kenny GP. Aging attenuates adenosine triphosphate-induced, but not muscarinic and nicotinic, cutaneous vasodilation in men. Microcirculation. 25(5):e12462, 2018

Tsuji B, Filingeri D, Honda Y, Eguchi T,Fujii N, Kondo N, Nishiyasu T. Reply to Parkes: Effect of hypocapnia on the sensitivity of hyperthermic hyperventilation and the cerebrovascular response in resting heated humans. J Appl Physiol. 124(5):1213, 2018

Fujii N, Nishiyasu T, Kenny GP. Reply to Carter and Green: HSP90: an unappreciated mediator of cutaneous vascular adaptation? J Appl Physiol. 1;124(2):522, 2018

Fujii N, Nishida Y, Ogawa T, Tanigawa S, and Nishiyasu T. Effects of work-matched moderate- and high-intensity warm-up on power output during 2-min supramaximal cycling. Biol Sport. 35(3):223-228, 2018.

Fujii N, Meade RD, Louie JC, Pegah A, Boulay P, Sigal RJ, Kenny GP. Effect of P2 receptor blockade on cutaneous vasodilation during rest and exercise in the heat in young men. Appl Physiol Nutr Metab. 43(3):312-315, 2018

Fujii N, Halili L, Nishiyasu T, Kenny GP. Voltage-gated potassium channels and NOS contribute to a sustained cutaneous vasodilation elicited by local heating in an interactive manner in young adults. Microvasc Res. 17:22-27, 2018

Fujii N, Meade RD, McNeely BD, Nishiyasu T, Sigal RJ, Kenny GP. Type 2 diabetes specifically attenuates purinergic skin vasodilatation without affecting muscarinic and nicotinic skin vasodilatation and sweating. Exp Physiol. 103(2):212-221, 2018

Meade RD, Fujii N, Poirier MP, Boulay P, Sigal RJ, Kenny GP. Oxidative stress does not influence local sweat rate during high intensity exercise. Exp Physiol. 103(2):172-178, 2018

Ichinose M, Matsumoto M, Fujii N, Yoshitake N, Nishiyasu T. Voluntary apnea during dynamic exercise activates the muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol. 314:H434-H442, 2018

Tsuji B, Filingeri D, Honda Y, Eguchi T, Fujii N, Kondo N, Nishiyasu T. Effect of hypocapnia on the sensitivity of hyperthermic hyperventilation and the cerebrovascular response in resting heated humans. J Appl Physiol. 124:225-233, 2018

2017

McNeely BD, Meade RD,Fujii N, Seely AJE, Sigal RJ, Kenny GP. Fluid replacement moderates oxidative stress- but not nitric oxide-mediated cutaneous vasodilation and sweating during prolonged exercise in the heat Am J Physiol Regul Integr Comp Physiol. 313(6):R730-R739, 2017

Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N. Do nitric oxide synthase and cyclooxygenase contribute to sweating response during passive heating in endurance-trained athletes? Physiol Rep. Sep;5(17). pii: e13403, 2017

Fujii N, Murakami E, Tsuji B, Kenny GP, Nagashima K, Kondo N, Nishiyasu T. Body temperature and cold sensation during and following exercise under temperate room conditions in cold-sensitive young trained females. Physiol Rep. Nov;5(20). pii: e13465, 2017

Fujii N, Zhang SY, McNeely BD, Nishiyasu T, Kenny GP. Heat shock protein 90 contributes to cutaneous vasodilation through activating nitric oxide synthase in young male adults exercising in the heat. J Appl Physiol. 123(4):844-850, 2017

Fujii N, McNeely BD, Nishiyasu T, and Kenny GP. Intradermal administration of atrial natriuretic peptide has no effect on sweating and cutaneous vasodilator responses in young male adults. Temperature. 4: 414-419, 2017

Dobashi K, Fujii N, Watanabe K, Tsuji B, Sasaki Y, Fujimoto T, Tanigawa S, Nishiyasu T. Effect of voluntary hypocapnic hyperventilation or moderate hypoxia on metabolic and heart rate responses during high-intensity intermittent exercise. Eur J Appl Physiol. 117(8):1573-1583, 2017

Amano T, Shitara Y, Fujii N, Inoue Y, Kondo N. Evidence for β-adrenergic modulation of sweating during incremental exercise in habitually trained males. J Appl Physiol. 123(1):182-189, 2017

Fujii N, Nikawa T, Tsuji B, Kenny GP, Kondo N, Nishiyasu T. Wearing graduated compression stockings augments cutaneous vasodilation but not sweating during exercise in the heat. Physiol Rep. May;5(9). pii: e13252, 2017

Fujii N, Meade R, Akbari P, Louie JC, Alexander L, Boulay P, Sigal R, Kenny GP. No effect of ascorbate on cutaneous vasodilation and sweating in older men and those with type 2 diabetes exercising in the heat. Physiol Rep. Apr;5(7). pii: e13238, 2017-

Amano T, Fujii N, Louie JC, Meade RD, Kenny GP. Individual variations in nitric oxide synthase-dependent sweating in young and older males during exercise in the heat: role of aerobic power. Physiol Rep. Mar;5(6). pii: e13208, 2017

Fujii N, Nikawa T, Tsuji B, Kondo N, Kenny GP, Nishiyasu T. Wearing graduated compression stockings augments cutaneous vasodilation in heat-stressed resting humans. Eur J Appl Physiol. 117(5):921-929, 2017

Fujii N, McNeely BD, Nishiyasu T, Kenny GP. Prostacyclin does not affect sweating but induces skin vasodilatation to a greater extent in older versus younger women: roles of NO and KCa channels. Exp Physiol. 102(5):578-586, 2017

Louie JC,Fujii N, Meade RD, McNeely BD, Kenny GP. The roles of KCa, KATP, and KV channels in regulating cutaneous vasodilation and sweating during exercise in the heat. Am J Physiol Regul Integr Comp Physiol. 312(5):R821-R827, 2017

Haqani B, Fujii N, Kondo N, Kenny GP. The mechanisms underlying the muscle metaboreflex modulation of sweating and cutaneous blood flow in passively heated humans. Physiol Rep. 5(3). pii: e13123, 2017

Fujii N, Louie JC, McNeely BD, Amano T, Nishiyasu T, Kenny GP. Mechanisms of nicotine-induced cutaneous vasodilation and sweating in young adults: roles for KCa, KATP, and KV channels, nitric oxide, and prostanoids. Appl Physiol Nutr Metab. Mar 22:1-9, 2017

Fujii N, McNeely BD, Zhang SY, Abdellaoui YC, Danquah MO, Kenny GP. Activation of protease-activated receptor 2 mediates cutaneous vasodilatation but not sweating: roles of nitric oxide synthase and cyclo-oxygenase. Exp Physiol. 1;102(2):265-272, 2017

Fujii N, Amano T, Halili L, Louie JC, Zhang SY, McNeely BD, Kenny GP. Intradermal administration of endothelin-1 attenuates endothelium-dependent and -independent cutaneous vasodilation via Rho kinase in young adults. Am J Physiol Regul Integr Comp Physiol. 12(1):R23-R30, 2017

Fujii N, Louie JC, McNeely BD, Zhang SY, Tran MA, and Kenny GP. Nicotinic receptor activation augments muscarinic receptor-mediated eccrine sweating but not cutaneous vasodilatation in young males. Exp Physiol. 102(2):245-254, 2017

Fujii N, McNeely BD, Kenny GP. Nitric oxide synthase and cyclooxygenase modulate β-adrenergic cutaneous vasodilatation and sweating in young men. J Physiol. 594(4):1173-1184, 2017

Ichinose M, Ichinose-Kuwahara TK, Watanabe K, Kondo N, Nishiyasu T. The carotid baroreflex modifies the pressor threshold of the muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol. 313(3) 650-657, 2017

2016

Louie JC, Fujii N, Meade RD, Kenny GP. The Roles of the Na+/K+-ATPase, NKCC, and K+ Channels in Regulating Local Sweating and Cutaneous Blood Flow during Exercise in Humans in vivo. Physiol Rep. Nov;4(22). pii: e13024, 2016

Fujii N, Dervis S, Sigal RJ, Kenny GP. Type 1 diabetes modulates cyclooxygenase- and nitric oxide-dependent mechanisms governing sweating but not cutaneous vasodilation during exercising in the heat. Am J Physiol Regul Integr Comp Physiol. 311(6):R1076-R1084, 2016

Fujii N, Halili L, Singh MS, Meade RD, Kenny GP. The effect of endothelin A and B receptor blockade on cutaneous vascular and sweating responses in young males during and following exercise in the heat. J Appl Physiol. 121(6):1379-1387, 2016

Fujii N, Notley SR, Minson CT, Kenny GP. Administration of prostacyclin modulates cutaneous blood flow but not sweating in young and older males: roles for nitric oxide and calcium-activated potassium channels. J Physiol. 594(21):6419-6429, 2016

Meade RD, Louie JC, Poirier MP, McGinn R, Fujii N, Kenny GP.　Exploring the mechanisms underpinning sweating: the development of a specialized ventilated capsule for use with intradermal microdialysis. Physiol Rep. Mar;4(6). pii: e12738, 2016

Fujii N, Louie JC, McNeely BD, Zhang SY, Tran MA, Kenny GP. K+ channel mechanisms underlying cholinergic cutaneous vasodilation and sweating in young humans: roles of KCa, KATP, and KV channels? Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R600-606, 2016

Louie JC, Fujii N, Meade RD, Kenny GP. The interactive contributions of Na+ /K+ -ATPase and nitric oxide synthase to sweating and cutaneous vasodilation during exercise in the heat. J Physiol. 594(12):3453-62, 2016.

Halili L, Singh MS, Fujii N, Alexander LM, Kenny GP. Endothelin-1 modulates methacholine-induced cutaneous vasodilation but not sweating in young human skin. J Physiol. 594(12):3439-52, 2016

Fujii N, Meade RD, Minson CT, Brunt VE, Boulay P, Sigal RJ, Kenny GP. Cutaneous blood flow during intradermal NO administration in young and older adults: roles for calcium-activated potassium channels and cyclooxygenase? Am J Physiol Regul Integr Comp Physiol. 310: R1081-R1087, 2016.

Fujii N, Singh MS, Halili L, Boulay P, Sigal RJ, Kenny GP. Cutaneous vascular and sweating responses to intradermal administration of prostaglandin E1 and E2 in young and older adults: a role for nitric oxide? Am J Physiol Regul Integr Comp Physiol. 310: R1064-R1072, 2016.

Fujii N, Meade RD, Alexander LM, Akbari P, Foudil-Bey I, Louie JC, Boulay P, Kenny GP. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat. J Appl Physiol. 120: 318-327, 2016.

Amano T, Ichinose M, Inoue Y, Nishiyasu T, Koga S, Kenny GP, Kondo N. Influence of forearm muscle metaboreceptor activation on sweating and cutaneous vascular responses during dynamic exercise. Am J Physiol Regul Integr Comp Physiol. 310(11) 1332-1339, 2016

Tsuji B, Hayashi K, Kondo N, Nishiyasu T. Characteristics of hyperthermia-induced hyperventilation in humans. Temperature. 18;3(1):146-60, 2016

Tsuji B, Honda Y, Kondo N, Nishiyasu T. Diurnal variation in the control of ventilation in response to rising body temperature during exercise in the heat. Am J Physiol Regul Integr Comp Physiol. 311: R401-409, 2016.

2015

Brunt VE, Fujii N, Minson CT. Endothelial-derived hyperpolarization contributes to acetylcholine-mediated vasodilation in human skin in a dose-dependent manner. J Appl Physiol. 119: 1015-1022, 2015.

Fujii N, Halili L, Singh MS, Meade RD, Kenny GP. Intradermal administration of ATP augments methacholine-induced cutaneous vasodilation but not sweating in young males and females. Am J Physiol Regul Integr Comp Physiol. 309: R912-R919, 2015.

Fujii N, Tsuji B, Honda Y, Kondo N, Nishiyasu T. Effect of short-term exercise-heat acclimation on ventilatory and cerebral blood flow responses to passive heating at rest in humans. J Appl Physiol. 119: 435-444, 2015.

Meade RD,Fujii N, Alexander LM, Paull G, Louie JC, Flouris AD, Kenny GP. Local infusion of ascorbate augments NO-dependent cutaneous vasodilatation during intense exercise in the heat. J Physiol. 593: 4055-4065, 2015.

Fujii N, Tsuchiya S, Tsuji B, Watanabe K, Sasaki Y, Nishiyasu T. Effect of voluntary hypocapnic hyperventilation on the metabolic response during Wingate anaerobic test. Eur J Appl Physiol. 115: 1967-1974, 2015.

Delliaux S, Ichinose M, Watanabe K,Fujii N, Nishiyasu T. Cardiovascular responses to forearm muscle metaboreflex activation during hypercapnia in humans. Am J Physiol Regul Integr Comp Physiol. 309: R43-R50, 2015.

Fujii N, Paull G, McGinn R, Meade RD , Stapleton JM, Akbari P, Kenny GP. Do nitric oxide synthase and cyclooxygenase contribute to the heat loss responses in older males exercising in the heat? J Physiol. 593: 3169-3180, 2015.

Fujii N, McGinn R, Halili L, Singh MS, Kondo N, Kenny GP. Cutaneous vascular and sweating responses to intradermal administration of ATP: a role for nitric oxide synthase and cyclooxygenase? J Physiol. 593: 2515-2525, 2015.

Fujii N, Meade RD, Paull G, McGinn R, Foudil-bey I, Akbari P, Kenny GP. Can intradermal administration of angiotensin II influence human heat loss responses during whole-body heat stress? J Appl Physiol. 118: 1145-1153, 2015.

Tsuji B, Honda Y, Ikebe Y,Fujii N, Kondo N, Nishiyasu T. Voluntary suppression of hyperthermia-induced hyperventilation mitigates the reduction in cerebral blood flow velocity during exercise in the heat. Am J Physiol Regul Integr Comp Physiol. 308: R669-R679, 2015.

Amano T, Ichinose M, Inoue Y, Nishiyasu T, Koga S, Kondo N. Modulation of muscle metaboreceptor activation upon sweating and cutaneous vascular responses to rising core temperature in humans. Am J Physiol Regul Integr Comp Physiol. 308(12) 990-997, 2015

Ichinose M, Ichinose-Kuwahara T, Kondo N, Nishiyasu T. Increasing blood flow to exercising muscle attenuates systemic cardiovascular responses during dynamic exercise in humans. Am J Physiol Regul Integr Comp Physiol. 309(10) 1234-1242, 2015

2014

Stapleton JM,Fujii N, McGinn R, McDonald K, Kenny GP. Age-related differences in postsynaptic increases in sweating and skin blood flow postexercise. Physiol Rep. 2: pii: e12078, 2014.

Fujii N, McGinn R, Stapleton J, Paull G, Meade RD, Kenny GP. Evidence for cyclooxygenase-dependent sweating in young males during intermittent exercise in the heat. J Physiol. 592: 5327-5339, 2014.

McGinn R, Paull G, Meade DR, Fujii N, Kenny GP. Mechanisms underlying the postexercise baroreceptor‐mediated suppression of heat loss. Physiol Rep. 2: no. e12168, 2014.

Fujii N, Honda Y, Komura K, Tsuji B, Sugihara A, Watanabe K, Kondo N, Nishiyasu T. Effect of voluntary hypocapnic hyperventilation on the relationship between core temperature and heat loss responses in exercising humans. J Appl Physiol. 117: 1317-1324, 2014.

Fujii N, McGinn R, Paull G, Stapleton JM, Meade RD, Kenny GP. Cyclooxygenase inhibition does not alter methacholine-induced sweating. J Appl Physiol. 117: 1055-1062, 2014.

Sugihara A, Fujii N, Tsuji B, Watanabe K, Niwa T, Nishiyasu T. Hypervolemia induced by fluid ingestion at rest: effect of sodium concentration. Eur J Appl Physiol. 114: 2139-2145, 2014.

Choi PJ, Brunt VE, Fujii N, Minson CT. New approach to measure cutaneous microvascular function: an improved test of NO-mediated vasodilation by thermal hyperemia. J Appl Physiol. 117: 277-283, 2014.

Stapleton JM, Fujii N, Carter M, Kenny GP. Diminished nitric oxide-dependent sweating in older males during intermittent exercise in the heat. Exp Physiol. 99: 921-932, 2014.

McGinn R,Fujii N, Swift B, Lamarche DT, Kenny GP. Adenosine receptor inhibition attenuates the suppression of postexercise cutaneous blood flow. J Physiol. 592: 2667-2678, 2014.

Fujii N, Brunt VE, Minson CT. Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers. Am J Physiol Heart Circ Physiol. 306: H1507-H1511, 2014.

Ichinose M, Maeda S, Kondo N, Nishiyasu T. Blood pressure regulation II: what happens when one system must serve two masters-oxygen delivery and pressure regulation? Eur J Appl Physiol. 114(3) 451-456, 2014

Watanabe K, Ichinose M, Tahara R, Nishiyasu T. Individual differences in the cardiac and vascular components of the pressor response to isometric handgrip exercise in humans. Am J Physiol Heart Circ Physiol. 306(2) H1568-1575, 2014

Amano T, Ichinose M, Nishiyasu T, Inoue Y, Koga S, Miwa M, Kondo N. Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans. Am J Physiol Regul Integr Comp Physiol. 306(10) R728-734, 2014

2013

Brunt VE, Fujii N, Minson CT. No independent, but an interactive, role of calcium-activated potassium channels in human cutaneous active vasodilation. J Appl Physiol. 115: 1290-1296, 2013.

Ichinose M, Watanabe K, Fujii N, Kondo N, Nishiyasu T. Muscle metaboreflex activation speeds the recovery of arterial blood pressure following acute hypotension in humans. Am J Physiol Heart Circ Physiol. 304: H1568-H1575, 2013.

Fujii N, Reinke MC, Brunt VE, Minson CT. Impaired acetylcholine-induced cutaneous vasodilation in young smokers: roles of nitric oxide and prostanoids. Am J Physiol Heart Circ Physiol. 304: H667-H673, 2013.

Fujii N, Ichinose M, Honda Y, Tsuji B, Watanabe K, Kondo N, Nishiyasu T. Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans. Eur J Appl Physiol. 113: 51-62, 2013.

2012

Ichinose M, Nishiyasu T. Arterial baroreflex control of muscle sympathetic nerve activity under orthostatic stress in humans. Frontiers Physiol. 3(314) 1-10, 2012

Ichinose M, Watanabe K, Fujii N, Nishiyasu T. Cardiovascular regulation during exercise-Contribution of peripheral reflexes. J Physical Fitness Sport Med. 1(3) 437-445, 2012

Fujii N, Honda Y, Delliaux S, Tsuji B, Watanabe K, Sugihara A, Kondo N, Nishiyasu T. Effect of voluntary hypocapnic hyperventilation on cutaneous circulation in resting heated humans. Am J Physiol Regul Integr Comp Physiol. 303: R975-R983, 2012.

Tsuji B, Honda Y, Fujii N, Kondo N, Nishiyasu T. Comparison of hyperthermic hyperventilation during passive heating and prolonged light and moderate exercise in the heat. J Appl Physiol. 113: 1388-1397, 2012.

Fujii N, Ogawa T, Ichinose M, Hayashi K, Nishiyasu T. Relationship between 800-m and 1500-m run times and anaerobic performance in competitive runners. Gazz Med Ital. 171: 491-501, 2012.

Fujii N, Honda Y, Ogawa T, Tsuji B, Kondo N, Koga S, Nishiyasu T. Short- term exercise-heat acclimation enhances skin vasodilation but not hyperthermic hyperpnea in humans exercising in a hot environment. Eur J Appl Physiol. 113: 51-62, 2012.

Tsuji B, Honda Y, Fujii N, Kondo N, Nishiyasu T. Effect of initial core temperature on hyperthermic hyperventilation during prolonged submaximal exercise in the heat. Am J Physiol Regul Integr Comp Physiol. 302: R94-R102, 2012.

Nishiyasu T, Tsukamoto R, Kawai K, Hayashi K, Koga S, Ichinose M. Relationships between the extent of apnea-induced bradycardia and the vascular response in the arm and leg during dynamic two-legged knee extension exercise. Am J Physiol Heart Circ Physiol. 302: H864-871, 2012

2011

Ichinose M, Delliaux S, Watanabe K,Fujii N, Nishiyasu T. Evaluation of muscle metaboreflex function through graded reduction in forearm blood flow during rhythmic handgrip exercise in humans. Am J Physiol Heart Circ Physiol. 301: H609-H616, 2011.

Amano T, Ichinose, Koga S, Inoue, Nishiyasu T, Kondo N. Sweating responses and the muscle metaboreflex under mildly hyperthermic conditions in sprinters and distance runners. J Appl Physiol. 111(2) 524-529, 2011

Hayashi K, Honda Y, Miyakawa N, Fujii N, Ichinose M, Koga S, Kondo N, and Nishiyasu T. The effect of CO₂ on the ventilatory sensitivity to rising body temperature during exercise. J Appl Physiol. 110: 1334-1341, 2011.

Nishiyasu T,Fujii N, Hayashi K, Tsuji B. Point:Counterpoint: Physiological significance of hyperthermia-induced hyperpnea for selective brain cooling in humans. J Appl Physiol. 110: 1575-1580, 2011.

2010

Watanabe K, Ichinose M, Fujii N, Matsumoto M, Nishiyasu T. Individual differences in the heart rate response to activation of the muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol. 299: H1708-H1714, 2010.

Ogawa T, Calbet JA, Honda Y, Fujii N, Nishiyasu T. The effects of breathing a helium-oxygen gas mixture on maximal pulmonary ventilation and maximal oxygen consumption during exercise in acute moderate hypobaric hypoxia. Eur J Appl Physiol. 110: 853-861, 2010.

2009

Hayashi K, Honda Y, Ogawa T, Kondo N, Nishiyasu T. The cross-sectional relationships among hyperthermia-induced hyperventilation, peak oxygen consumption, and the cutaneous vasodilatory re-sponse during exercise. Eur J Appl Physiol. 107(5):527-534, 2009

2008

Ichinose M, Saito M, Kondo N, Nishiyasu T. Baroreflex and Muscle Metaboreflex: Control of Muscle Sympathetic Nerve Activity. Med Sci Sport Exer. 40(12) 2037-2045, 2008

Fujii N, Honda Y, Hayashi K, Kondo N, Nishiyasu T. Effect of hypohydration on hyperthermic hyperpnea and cutaneous vasodilation during exercise in men. J Appl Physiol. 105: 1509-1518, 2008.

Fujii N, Honda Y, Hayashi K, Kondo N, Koga S, Nishiyasu T. Effects of chemoreflexes on hyperthermic hyperventilation and cerebral blood velocity in resting heated humans. Exp Physiol. 93: 994-1001, 2008.

Ichinose M, Saito M, Fujii N, Ogawa T, Hayashi K, Kondo N, Nishiyasu T. Modulation of the control of muscle sympathetic nerve activity during incremental leg cycling. J Physiol. 586: 2753-2766, 2008.

Fujii N, Honda Y, Hayashi K, Soya H, Kondo N, Nishiyasu T. Comparison of hyperthermic hyperpnea elicited during rest and submaximal, moderate-intensity exercise. J Appl Physiol. 104: 998-1005, 2008.

2007

Nishiyasu T, Hayashida S, Kitano A, Nagashima K, Ichinose M. Effects of posture on peripheral vascular responses to lower body positive pressure. Am J Physiol Heart Circ Physiol. 293(1), 2007

Ichinose M, Koga S, Fujii N, Kondo N, Nishiyasu T. Modulation of the spontaneous beat-to-beat fluctuations in peripheral vascular resistance during activation of muscle metaboreflex. Am J Physiol Heart Circ Physiol. 293: H416-H424, 2007.

Ogawa T, Hayashi K, Ichinose M, Nishiyasu T. Relationship between resting ventilatory chemosensitivity and maximal oxygen uptake in moderate hypobaric hypoxia, J Appl Physiol. 103(4) 1221-1226, 2007

Ogawa T, Hayashi K, Ichinose M, Wada H, Nishiyasu T. Metabolic response during intermittent graded sprint running in moderate hypobaric hypoxia in competitive middle-distance runners. Eur J Appl Physiol. 99(1) 39-46, 2007

2006

Ichinose M, Saito M, Fujii N, Kondo N, Nishiyasu T. Modulation of the control of muscle sympathetic nerve activity during severe orthostatic stress. J Physiol. 576: 947-958, 2006.

Ichinose M, Saito M, Kondo N, Nishiyasu T. Time-dependent modulation of arterial baroreflex control of muscle sympathetic nerve activity during isometric exercise in humans. Am J Physiol Heart Circ Physiol. 290: H419-H426, 2006.

Nishiyasu T, Ichinose M. Comment on Point:Counterpoint”The muscle metaboreflex does/does not restore blood flow to contracting muscles”. J Appl Physiol. 100: 750, 2006

Hayashi K, Honda Y, Ogawa T, Kondo N, Nishiyasu T. Relationship between ventilatory response and body temperature during prolonged submaximal exercise. J Appl Physiol. 100: 414-20, 2006

Nishiyasu N, Ichinose M, Kondo N, Saito M. Blood flow regulation during exercise. Journal of Health, Physical Education and Recreation 55: 901-906, 2006

2005

Ogawa T, Ohba K, Nabekura Y, Nagai J, Hayashi K, Wada H, Nishiyasu T. Intermittent short-term graded running performance in middle-distance runners in hypobaric hypoxia. Eur J Appl Physiol. 94(3):254-261, 2005

Kitano A, Shoemaker JK, Ichinose M, Wada H, Nishiyasu T. Comparison of cardiovascular responses between lower body negative pressure and head-up tilt. J Appl Physiol. 98: 2081-2086, 2005

Ichinose M, Nishiyasu T. Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans. Am J Physiol Heart Circ Physiol. 288: H1532-H1538, 2005.

2004

Ichinose M, Saito M, Ogawa T, Hayashi K, Kondo N, Nishiyasu T. Modulation of the control of muscle sympathetic nerve activity during orthostatic stress in humans. Am J Physiol Heart Circ Physiol. 287: H2147-H2153, 2004.

Ichinose M, Saito M, Kitano A, Hayashi K, Kondo N, Nishiyasu T. Modulation of arterial baroreflex dynamic response during mild orthostatic stress in humans. J Physiol. 577: 321-330, 2004.

Ichinose M, Saito M, Wada H, Kitano A, Kondo N, Nishiyasu T. Modulation of arterial baroreflex control of muscle sympathetic nerve activity by muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol. 287: H701-H707, 2004.

Hayashi K, Honda Y, Ogawa T, Wada H, Kondo N, Nishiyasu T. Effects of brief leg cooling after moderate exercise on cardiorespiratory responses to subsequent exercise in the heat. Eur J Appl Physiol. 92(4-5):414-420, 2004

2002

Ichinose M, Saito M, Wada H, Kitano A, Kondo N, Nishiyasu T. Modulation of arterial baroreflex dynamic response during muscle metaboreflex activation in humans. J Physiol. 544: 939-948, 2002.

External Funds

Research Projects	Project Period	Principal Investigator	Research Fund
Elucidation of a mechanisms of hyperthermia-induced hyperventilation and application of the countermeasures	2017 — 2020	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(A)	\42,640,000
New mechanisms for heat stroke during exercise in the heat and development of the countermeasures	2013 — 2016	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(A)	\46,410,000
Development of smart treadmill by using virtual technology for athletes	2013 — 2014	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Exploratory Research	\3,900,000
Interaction in peripheral reflexes -Individual difference and training effects	2010 — 2012	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (B)	¥17,810,000
Development of new Kanoe ergometer with Virtual technology	2011 — 2012	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Challenging Exploratory Research	¥3,900,000
Integrative responses between peripheral reflexes and the effects of exercise training	2007 — 2009	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (B)	¥20,150,000
Development of 3D athletic heart valuation for database	2005 — 2006	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Exploratory Research	¥4,300,000
Effects of active muscles on cardiovascular and hormonal responses during exercise and training	2004 — 2006	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B)	¥15,200,000
Development of oxygen up-take measurement device with CCD image	2002 — 2003	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Exploratory Research	¥3,300,000
Effects of afferents activities from active muscles on cardi-ovascular and hormonal responses during exercise	2001 — 2003	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B)	¥15,900,000
Development of multifunctional lower body pressure device	2000 — 2001	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(B)	¥10,200,000
Performance assessment of peripheral vascular monitoring device (ASTRIM) under hypoxic conditions	2001 — 2001	Takeshi NISHIYASU	/company-commissioned research
Assessment of peripheral vascular monitoring device (ASTRIM)	2000 — 2000	Takeshi NISHIYASU	/company-commissioned research
Mechanisms of cardiovascular regulation during rhythmic exercise -New study technique focused on muscle mecha-noreflex	1997 — 1998	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Encouragement of Young Scientists (A)	¥2,100,000
Effect of exercise training that stimulate a muscle chemoreceptor selectively on blood-pressure regulation	1995 — 1995	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Encouragement of Young Scientists (A)	¥900,000
Effect of exercise training on blood-pressure regulation with muscle chemoreceptor -longitudinal training	1994 — 1994	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Encouragement of Young Scientists (A)	¥1,000,000
Effect of exercise training on blood-pressure regulation with muscle chemoreceptor	1993 — 1993	Takeshi NISHIYASU	Japan Society for the Promotion of Science/Grant-in-Aid for Encouragement of Young Scientists (A)	¥900,000
Roles of TRP channels in the regulation of heat loss responses	2020-04 — 2022-03	Naoto FUJII	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research (B)	¥17,680,000
Effect of growth hormone on exercise mediated improvement of heat tolerance	2020-04 — 2022-03	Naoto FUJII	The Nakatomi Foundation	¥1,500,000
Mechanisms underlying heat loss responses	2019-04 — 2020-03	Naoto FUJII	Japan Society for the Promotion of Science/Leading Initiative for Excellent Young Researchers (LEAD-ER)	¥2,000,000
Mechanisms underlying heat loss responses	2018-04 — 2019-03	Naoto FUJII	Japan Society for the Promotion of Science/Leading Initiative for Excellent Young Researchers (LEAD-ER)	¥9,000,000
Mechanisms underlying heat loss responses	2017-11 — 2018-03	Naoto FUJII	Japan Society for the Promotion of Science/Leading Initiative for Excellent Young Researchers (LEAD-ER)	¥9,000,000
The influence of galanin on heat loss responses	2019 — 2021	Naoto FUJII	Japan Society for the Promotion of Science/Grant-in-Aid for challenging Exploratory Research	¥6,500,000
The influence of CGRP on heat loss responses	2018-12 — 2020-04	Naoto FUJII	Uehara Memorial Foundation	¥2,000,000
Mechanisms underlying heat loss responses	2017 — 2019	Naoto FUJII	Japan Society for the Promotion of Science/Grant-in-Aid for Young Scientists(S)	¥25,610,000

Distinctions/Awards

The International Academic Exchange Award for outstanding international academic activity. Japanese Society of Physical Fitness and Sports Medicine. Kohei Dobashi. 2019-9.

Young incentive award, The 33th meeting for exercise and body temperature,
Title: The effects of cold air inhalation on body temperature and cardiorespiratory responses during inter-mittent exercise in the heat. Keisuke Kashima, Tomomi Fujimoto, Naoto Fujii, Yasushi Honda, Narihiko Kondo, Takesni Nishiyasu, 2019-9.

Poster 1st prize. 18th International Conference on Environmental Ergomomics. Effects of pre-exercise voluntary hypocapnic hyperventilation on cardiovascular responses to simultaneous initiation of exercise and apnea. Sakamoto Mizuki, Ichinose Masashi, Dobashi Kohei, Matsutake Ryoko, Fujii Naoto, Nishiyasu Takeshi. 2019-7.

Oral presentation 1st prize. 17th International Conference on Environmental Ergomomics. Separate effects of voluntary hyperventilation and resultant hypocapnia on metabolic and cardiovascular responses during and following supramaximal exercise. Dobashi Kohei, Fujii Naoto, Fujimoto Tomomi, Tanigawa Satoru, Ichinose Masashi, Nishiyasu Takeshi. 2017-11