研究論文
2024
Otsuka J, Okamoto Y, Enoki Y, Maejima D, Fujii N, Kenny GP, Mündel T, Cotter JD, Amano T. Effects of ingesting beverages containing glycerol and sodium with isomaltulose or sucrose on fluid retention in young adults: a single-blind, randomized crossover trial. Appl Physiol Nutr Metab. 2024 May 1; 49(5):667-679.
Fujii N, Igarashi Y, Ishii Y, Ito E, Lai YF, Tanabe Y, Fujimoto T, Ogawa K, Nabekura Y, Hiroyama T, Nishiyasu T. Menthol alleviates post-race elevations in muscle soreness and metabolic and respiratory stress during running. Eur J Appl Physiol. 2024 Apr 2. Online ahead of print.
Lee BJ, Flood TR, Galan-Lopez N, McCormick JJ, King KE, Fujii N, Kenny GP. Changes in surrogate markers of intestinal epithelial injury and microbial translocation in young and older men during prolonged occupational heat stress in temperate and hot conditions. Eur J Appl Physiol. 2024 Apr;124(4):1049-1062.
Maimaituxun G, Amano T, Kenny GP, Mündel T, Kajiki M, Tagawa K, Katagiri A, Tanabe Y, Watanabe K, Nishiyasu T, Kondo N, Fujii N. GH and IGF-1 in skin interstitial fluid and blood are associated with heat loss responses in exercising young adults. Eur J Appl Physiol. 2024 Mar 6. Online ahead of print.
Tanabe Y, Kondo E, Sagayama H, Shimizu K, Yasumatsu M, Nakamura D, Fujii N, Takahashi H. Impact of curcumin supplementation on exercise performance and muscle damage after a soccer match: a double-blind placebo-controlled cross-over study. Eur J Appl Physiol. 2024 Mar 4. Online ahead of print.
Dobashi K, Fukazawa Y, Katagiri A, Enomoto Y, Nishiyasu T, Fujii N. Caffeine Improves Simulated 800-m Run Performance without Affecting Severe Exercise-Induced Arterial Hypoxemia. Med Sci Sports Exerc. 2024 Feb 1;56(2):350-361.
Lei TH, Lin C, Amano T, Ooue A, Mündel T, Cotter JD, Fujii N, Nishiyasu T, Kondo N. Comparing thermoregulatory responses between short and long moderate intensity intermittent exercise protocols with the same duty cycle. J Therm Biol. 2024 Jan:119:103750.
2023
Lei TH, Wang IL, Chen YM, Liu XH, Fujii N, Koga S, Perry B, Mundel T, Wang F, Cao Y, Dobashi K, Kondo N, Li HY, Goulding RP. Critical power is a key threshold determining the magnitude of post-exercise hypotension in non-hypertensive young males. Exp Physiol. 2023 Nov;108(11):1409-1421.
Fujii N, Rakwal R, Shibato J, Tanabe Y, Kenny GP, Amano T, Mündel T, Lei TH, Watanabe K, Kondo N, Nishiyasu T. Galanin receptors modulate cutaneous vasodilation elicited by whole-body and local heating but not thermal sweating in young adults. Eur J Pharmacol. 2023 Sep 5:954:175904.
Fujii N, Tanabe Y, Amano T, Watanabe K, Kondo N, Nishiyasu T, Kenny GP. Serum, interstitial, and sweat ATP in humans exposed to heat stress: insights into roles of ATP in the heat loss responses. Clin Physiol Funct Imaging. 2023 Sep;43(5):336-344.
Katagiri A, Fujii N, Dobashi K, Lai YF, Tsuji B, Nishiyasu T. Sodium bicarbonate reduces ventilation without altering core temperature threshold or sensitivity of hyperthermia-induced hyperventilation in exercising humans. Am J Physiol Regul Integr Comp Physiol. 2023 Jul 1;325(1):R69-R80.
Journeay WS, McCormick JJ, King KE, Notley SR, Goulet N, Fujii N, Amano T, Kenny GP. Impacts of age, diabetes, and hypertension on serum endothelial monocyte-activating polypeptide-II after prolonged work in the heat. Am J Ind Med. 2023 Jul;66(7):610-619.
Tanabe Y, Suzuki S, Kojima J, Matsui T, Watanabe K, Nishiyasu T, Fujii N. Thermal stress, hydration, and salivary and respiratory stress markers in curling players performing a match in the cold. Scand J Med Sci Sports. 2023 Jul;33(7):1079-1090.
King KE, McCormick JJ, Notley SR, Boulay P, Fujii N, Amano T, Kenny GP. Serum klotho concentrations in older men with hypertension or type 2 diabetes during prolonged exercise in temperate and hot conditions. Eur J Appl Physiol. 2023 Jul;123(7):1519-1527.
Amano T, Fujii N, Quan YS, Kenny GP, Kondo N, Yamashita H, Inoue Y. In vivo assessments of microneedle arrays and iontophoresis of pilocarpine in human palmar sweating. J Control Release. 2023 Jun;358:161-170.
Fujii N, Omori S, Kataoka Y, Maimaituxun G, Bailey SJ, Lloyd AB, Arnold JT, Amano T, Tanabe Y, Omi N, Watanabe K, Nishiyasu T. Dietary nitrate supplementation increases nitrate and nitrite concentrations in human skin interstitial fluid. Nitric Oxide. 2023 May1:134-135:10-16.
Delliaux S, Ichinose M, Watanabe K, Fujii N, Nishiyasu T. Muscle metaboreflex activation during hypercapnia modifies nonlinear heart rhythm dynamics, increasing the complexity of the sinus node autonomic regulation in humans. Pflugers Arch. 2023 Apr;475(4):527-539.
Goulet N, et al. Among authors: Fujii N. Elevations in serum brain-derived neurotrophic factor following occupational heat stress are not influenced by age or common chronic disease. Temperature (Austin). 2023 Feb 23;10(4):454-464.
Tagawa K, Tsuru Y, Yokoi K, Aonuma T, Hashimoto J. Being overweight worsens the relationship between urinary sodium excretion and albuminuria: the Wakuya study. Eur J Clin Nutr in press
2022
Dobashi K, Katagiri A, Fujii N, Nishiyasu T. Combined Effects of Hypocapnic Hyperventilation and Hypoxia on Exercise Performance and Metabolic Responses During the Wingate Anaerobic Test. Int J Sports Physiol Perform. 2022 Dec 15;18(1):69-76.
Takada S, Otsuka J, Okamoto Y, Watanabe D, Aoki M, Fujii N, Kenny GP, Enoki Y, Maejima D, Amano T. Effects of ingestion of isomaltulose beverage on plasma volume and thermoregulatory responses during exercise in the heat. Eur J Appl Physiol. 2022 Dec;122(12):2615-2626.
Dobashi K, Ichinose M, Fujii N, Fujimoto T, Nishiyasu T. Effects of Pre-Exercise Voluntary Hyperventilation on Metabolic and Cardiovascular Responses During and After Intense Exercise. Res Q Exerc Sport. 2022 Sep 28:1-12.
McGarr GW, King KE, Cassan CJM, Janetos KT, Fujii N, Kenny GP. Involvement of nitric oxide synthase and reactive oxygen species in TRPA1-mediated cutaneous vasodilation in young and older adults. Microvasc Res.2023 Jan;145:104443.
Fujii N, Kataoka Y, Lai YF, Shirai N, Hashimoto H, Nishiyasu T. Ingestion of carbonated water increases middle cerebral artery blood velocity and improves mood states in resting humans exposed to ambient heat stress. Physiol Behav. ahead of print. 2022
Zheng H, Badenhorst CE, Lei TH, Che Muhamed AM, Liao YH, Fujii N, Kondo N, Mündel T. Do E 2 and P 4 contribute to the explained variance in core temperature response for trained women during exertional heat stress when metabolic rates are very high? Eur J Appl Physiol. ahead of print. 2022
Fujii N, Amano T, Kenny GP, Mündel T, Lei TH, Honda Y, Kondo N, Nishiyasu T. TMEM16A blockers T16Ainh-A01 and benzbromarone do not modulate the regulation of sweating and cutaneous vasodilatation in humans in vivo. Exp Physiol. 107(8):844-853. 2022
Cao Y, Fujii N, Fujimoto T, Lai YF, Ogawa T, Hiroyama T, Enomoto Y, Nishiyasu T. CO 2-Enriched Air Inhalation Modulates the Ventilatory and Metabolic Responses of Endurance Runners During Incremental Running Under Hypobaric Hypoxia. High Alt Med Biol. 23(2):125-134. 2022
Fujii N, Meade RD, Schmidt MD, King KE, Boulay P, Ruzicka M, Amano T, Kenny GP. The effect of acute intradermal administration of ascorbate on heat loss responses in older adults with uncomplicated controlled hypertension. Exp Physiol. 107(8):834-843. 2022
Moriyama S, Ichinose M, Dobashi K, Matsutake R, Sakamoto M, Fujii N, Nishiyasu T. Hypercapnia elicits differential vascular and blood flow responses in the cerebral circulation and active skeletal muscles in exercising humans. Physiol Rep. 10(8):e15274. 2022
Amano T, Fujii N, Kenny GP, Okamoto Y, Inoue Y, Kondo N. Effects of tetraethylammonium-sensitive K + channel blockade on cholinergic and thermal sweating in endurance-trained and untrained men. Exp Physiol. 107(5):441-449. 2022
King KE, McCormick JJ, Notley SR, Fujii N, Kenny GP. Serum klotho concentrations in young and older men during prolonged exercise in temperate and hot conditions. Curr Aging Sci. 15(2):180-185. 2022
Amano T, Watanabe D, Otsuka J, Okamoto Y, Takada S, Fujii N, Kenny GP, Enoki Y, Maejima D. Comparison of hydration efficacy of carbohydrate-electrolytes beverages consisting of isomaltulose and sucrose in healthy young adults: A randomized crossover trial. Physiol Behav. 15;249:113770. 2022
McCormick JJ, King KE, Notley SR, Fujii N, Boulay P, Sigal RJ, Kenny GP. Exercise in the heat induces similar elevations in serum irisin in young and older men despite lower resting irisin concentrations in older adults. J Therm Biol. 104:103189. 2022
McGarr GW, King KE, Akerman AP, Fujii N, Ruzicka M, Kenny GP. Influence of uncomplicated, controlled hypertension on local heat-induced vasodilation in nonglabrous skin across the body. Am J Physiol Regul Integr Comp Physiol. 1;322(4):R326-R335. 2022
Fujii N, McGarr GW, Amano T, Boulay P, Nishiyasu T, Kenny GP. Does aging alter skin vascular function in humans when spatial variation is considered? Microcirculation. 29(2):e12743. 2022
Kataoka Y, Kenny G, Nishiyasu T, Amano T, Mundel T, Zheng H, Lei TH, Watanabe K, Fujii N. TRPA1 channel activation with cinnamaldehyde induces cutaneous vasodilation through NOS, but not COX and KCa channel, mechanisms in humans. J Cardio Pharmacol. 1;79(3):375-382, 2022
2021
Tanabe Y, Fujii N, Suzuki K. Dietary Supplementation for Attenuating Exercise-Induced Muscle Damage and Delayed-Onset Muscle Soreness in Humans Nutrients. 24;14(1):70. 2021
Zheng H, Badenhorst CE, Lei TH, Che Muhamed AM, Liao YH, Amano T, Fujii N, Nishiyasu T, Kondo N, Mundel T. Measurement error of self-paced exercise performance in athletic women is not affected by ovulatory status or ambient environment. J Appl Physiol. 131(5):1496-1504, 2021
Katagiri A, Kitadai Y, Miura A, Fukuba Y, Fujii N, Nishiyasu T, Tsuji B. Sodium bicarbonate ingestion mitigates the heat-induced hyperventilation and reduction in cerebral blood velocity during exercise in the heat. J Appl Physiol. 131(5):1617-1628, 2021
Fujii N, Kenny GP, Amano T, Honda Y, Kondo N, Nishiyasu T. Na+/K+-ATPase plays a major role in mediating cutaneous thermal hyperemia achieved by local skin heating to 39℃. J Appl Physiol. 131(5):1408-1416, 2021
Fujii N, Sugihara A, Watanabe K, Niwa T, Katagiri A, Moriyama S, Miyanagi I, Kojima J, Nishiyasu T. Carbohydrate hastens hypervolemia achieved through ingestion of aqueous sodium solution in resting euhydrated humans. Eur J Appl Physiol.121(12):3527-3537, 2021
Fujii N, Fujisawa K, Dobashi K, Cao Y, Matsutake R, Lai, YF, Nishiyasu T. Effects of High-intensity Exercise Repetition Number during Warm-up on Physiological Responses, Perceptions, Readiness, and Performance. Res Q Exerc Sport. ahead of print, 2021
Saci S, McGarr GW, Fujii N, Kenny GP. Regional cutaneous vasodilator responses to rapid and gradual local heating in young adults. J Therm Biol. 99:102978. 2021
Fujimoto T, Fujii N, Dobashi K, Cao Y, Matsutake R, Takayanagi M, Kondo N, Nishiyasu T. Effects of low-intensity exercise on local skin and whole-body thermal sensation in hypothermic young males. Physiol Behav. 240:113531, 2021
McGarr GW, King KE, Saci S, Leduc D, Akerman AP, Fujii N, Kenny GP. Regional variation in nitric oxide-dependent cutaneous vasodilatation during local heating in young adults. Exp Physiol. 106(8):1671-1678, 2021
Amano T, Katayama S, Okamoto Y, Otsuka J, Fujii N, Kenny GP, Nishiyasu T, Enoki Y, Maejima D. Comparisons of isomaltulose, sucrose, and mixture of glucose and fructose ingestions on postexercise hydration state in young men. Eur J Nutr. 60(8):4519-4529, 2021
Fujii N, McGarr GW, Amano T, Nishiyasu T, Sigal RJ, Kenny GP. Type 2 diabetes impairs vascular responsiveness to nitric oxide, but not the venoarteriolar reflex or post-occlusive reactive hyperaemia in forearm skin. Exp Dermatol. 30(12)1807-1813, 2021
Lei TH, Fujiwara M, Gerrett N, Amano T, Mundel T, Inouc Y, Okushima D, Nishiyasu T, Kondo N. The effect of seasonal acclimatization on whole-body heat loss response during exercise in a hot humid environment with different air velocity. J Appl Physiol. 131(2):520-531, 2021
Otsuka J, Okamoto Y, Fujii N, Enoki Y, Maejima D, Nishiyasu T, Amano T. Effects of Isomaltulose Ingestion on Thermoregulatory Responses during Exercise in a Hot Environment. Int J Environ Res Public Health. 18(11):5760, 2021
Tanabe Y, Akazawa N, Nishimaki M, Shimizu K, Fujii N, Takahashi H. Effects of 6-(Methylsulfinyl)hexyl Isothiocyanate Ingestion on Muscle Damage after Eccentric Exercise in Healthy Males: A Pilot Placebo-Controlled Double-Blind Crossover Study. J Diet Suppl. 19(5):656-671.
Zheng H, Badenhorst CE, Lei TH, Liao YH, Che Muhamed AM, Fujii N, Kondo N, Mündel T. Menstrual phase and ambient temperature do not influence iron regulation in the acute exercise period. Am J Physiol Regul Integr Comp Physiol. 320(6):R780-R790, 2021
Tanabe Y, Shimizu K, Sagayama H, Fujii N, Takahashi H. Urinary N-terminal fragment of titin: A surrogate marker of serum creatine kinase activity after exercise-induced severe muscle damage. J Sports Sci. 39(13):1437-1444, 2021
Arnold JT, Bailey SJ, Hodder SG, Fujii N, Lloyd AB. Independent and combined impact of hypoxia and acute inorganic nitrate ingestion on thermoregulatory responses to the cold. Eur J Appl Physiol. 121:1207-1218, 2021
Fujii N, Kenny GP, McGarr GW, Amano T, Honda Y, Kondo N, Nishiyasu T. TRPV4 channel blockade does not modulate skin vasodilation and sweating during hyperthermia or cutaneous post-occlusive reactive and thermal hyperemia. Am J Physiol Regul Integr Comp Physiol. 320:R563-R573, 2021
Fujii N, Fujimoto T, Cao Y, Dobashi K, Matsutake R, Amano T, Wanatabe K, Nishiyasu T. Caffeine Exacerbates Hyperventilation and Reductions in Cerebral Blood Flow in Physically Fit Males Exercising in the Heat. Med Sci Sports Exerc. 53(4):845-852, 2021
Fujii N, McGarr GW, Notley SR, Boulay P, Sigal RJ, Amano T, Nishiyasu T, Poirier MP, Kenny GP. Effects of short-term heat acclimation on whole-body heat exchange and local nitric oxide synthase- and cyclooxygenase-dependent heat loss responses in exercising older men. Exp Physiol. 106(2):450-462, 2021
Tanabe Y, Nakata Y, Zempo-Miyaki A, Hieda MY, Choi Y, Fujii N, Maeda S. Different degree of intervention in 6-month weight-loss support and arterial stiffness: Secondary analysis of a randomized controlled trial. Obes Res Clin Pract. 15(1):93-95, 2021
McGarr GW, Muia CM, Saci S, Fujii N, Kenny GP. KCa channels are major contributors to ATP-induced cutaneous vasodilation in healthy older adults. Microvasc Res. 133:104096, 2021
2020
Amano T, Fujii N, Kenny GP, Nishiyasu T, Inoue Y, Kondo N. The relative contribution of α- and β-adrenergic sweating during heat exposure and the influence of sex and training status. Exp Dermatol. 29(12):1216-1224, 2020
Amano T, Fujii N, Kenny GP, Okamoto Y, Inoue Y, Kondo N. Effects of L-type voltage-gated Ca 2+ channel blockade on cholinergic and thermal sweating in habitually trained and untrained men. Am J Physiol Regul Integr Comp Physiol. 319(5):R584-R591, 2020
McGarr GW, Fujii N, Schmidt MD, Muia CM, Kenny GP. Heat shock protein 90 modulates cutaneous vasodilation during an exercise-heat stress, but not during passive whole-body heating in young women. Physiol Rep. 8(16):e14552, 2020
Amano T, Sekihara S, Fujii N, Kenny GP, Inoue Y, Kondo N. Does the iontophoretic application of bretylium tosylate modulate sweating during exercise in the heat in habitually trained and untrained men? Exp Physiol. 105(10):1692-1699, 2020
McCormick JJ, King KE, Côté MD, McManus MK, Topshee SM, Hsu HS, Fujii N, Kenny GP. Regulation of autophagy following ex vivo heating in peripheral blood mononuclear cells from young adults. J Therm Biol. 91:102643, 2020
Arnold JT, Lloyd AB, Bailey SJ, Fujimoto T, Matsutake R, Takayanagi M, Nishiyasu T, Fujii N. The nitric oxide dependence of cutaneous microvascular function to independent and combined hypoxic cold exposure. J Appl Physiol. 129(4):947-956, 2020
Dobashi K, Fujii N, Ichinose M, Fujimoto T, Nishiyasu T. Volunatry hypocapnic hyperventilation lasting 5 and 20 min similarly reduce aerobic metabolism without affecting power outputs during Wingate anaerobic test. Eur J Sport Sci. 17:1-8, 2020
Fujii N, McGarr GW, Amano T, Sigal RJ, Boulay P, Nishiyasu T, Kenny GP. Ageing augments β‐adrenergic cutaneous vasodilatation differently in men and women with no effect on β‐adrenergic sweating. Exp Physiol. 105(10):1720-1729, 2020
Fujii N, McGarr GW, Ghassa R, Schmidt MD, McCormick JJ, Nishiyasu T, Kenny GP. Sex-differences in Cholinergic, Nicotinic, and β-adrenergic Cutaneous Vasodilation: Roles of Nitric Oxide Synthase, Cyclooxygenase, and K + Channels. Microvasc Res. 131:104030, 2020
Schmidt MD, McGarr GW, Muia CM, Fujii N, Amano T, Kenny GP. Regional Influence of Nitric Oxide on Cutaneous Vasodilatation and Sweating During Exercise-Heat Stress in Young Men. Exp Physiol. 105(5):773-782, 2020
Ogawa T, Nagao M, Fujii N, Nishiyasu T. Effect of inspiratory muscle-loaded exercise training on peak oxygen uptake and ventilatory response during incremental exercise under normoxia and hypoxia. BMC Sports Sci Med Rehabil. 15;12:25, 2020
Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N. Does α 1-adrenergic Receptor Blockade Modulate Sweating During Incremental Exercise in Young Endurance-Trained Men? Eur J Appl Physiol. 120(5):1123-1129, 2020
Fujii N, McGarr GW, Kenny GP, Amano T, Honda Y, Kondo N, Nishiyasu T. NO mediated activation of KATP channels contributes to cutaneous thermal hyperaemia in young adults. Am J Physiol Regul Integr Comp Physiol. 318(2):R390-R398, 2020
McGarr GW, Ghassa R, Fujii N, Amano T, Kenny GP. Exp Physiol. Regional contributions of nitric oxide synthase to cholinergic cutaneous vasodilatation and sweating in young men. Exp Physiol. 105(2):236-243, 2020
McGarr GW, Fujii N, Muia CM, Nishiyasu T, Kenny GP. Intradermal Administration of Atrial Natriuretic Peptide Attenuates Cutaneous Vasodilation but Not Sweating in Young Men during Exercise in the Heat. Skin Pharmacol Physiol. 31:1-8, 2020
Fujii N, McGarr GW, McNeely BD, Ichinose M, Nishiyasu T, Kenny GP. KCa and KV channels modulate the venoarteriolar reflex in non-glabrous human skin with no roles of KATP channels, NOS, and COX. Eur J Pharmacol. 5;866:172828, 2020
Fujii N, McGarr GW, Ichinose M, Nishiyasu T, Kenny GP. Tetraethylammonium, glibenclamide, and 4-aminopyridine modulate post-occlusive reactive hyperemia in non-glabrous human skin with no roles of NOS and COX. Microcirculation. 27(1):e12586, 2020
2019
Muia CM, McGarr GW, Schmidt MD, Fujii N, Amano T, Kenny GP. Contribution of nitric oxide synthase to cutaneous vasodilatation and sweating in men of black-African and Caucasian descent during exercise in the heat. Exp Physiol. 104(12):1762-1768, 2019
Fujii N, Amano T, Kenny GP, Honda Y, Kondo N, Nishiyasu T. Nicotinic receptors modulate skin perfusion during normothermia, and have a limited role in skin vasodilatation and sweating during hyperthermia. Exp Physiol. 104(12):1808-1818, 2019
Fujii N, McGarr GW, Sigal RJ, Boulay P, Nishiyasu T, Kenny GP. Ageing augments nicotinic and adenosine triphosphate-induced, but not muscarinic, cutaneous vasodilatation in women. Exp Physiol. 104(12):1801-1807, 2019
Notley SR, Poirier MP, Sigal RJ, D’Souza A, Flouris AD, Fujii N, Kenny GP. Exercise Heat Stress in Patients With and Without Type 2 Diabetes. JAMA. Oct 8;322(14):1409-1411, 2019
Amano T, Sugiyama Y, Okumura J, Fujii N, Kenny GP, Nishiyasu T, Inoue Y, Kondo N, Sasagawa K, Enoki Y, Maejima D. Effects of isomaltulose ingestion on postexercise hydration state and heat loss responses in young men. Exp Physiol. 104(10):1494-1504, 2019.
Fujii N, Hatam K, McGarr GW, Meade RD, Boulay P, Nishiyasu T, Kenny GP. Exogenous Activation of Protease-Activated Receptor 2 Attenuates Cutaneous Vasodilatation and Sweating in Older Men Exercising in the Heat. Skin Pharmacol Physiol. 32(5):235-243, 2019
Fujii N, Kenny GP, Amano T, Honda Y, Kondo N, Nishiyasu T. Evidence for TRPV4 channel induced skin vasodilatation through NOS, COX, and KCa channel mechanisms with no effect on sweat rate in humans. Eur J Pharmacol. 5;858:172462, 2019.
McGarr GW,Fujii N, McNeely BD, Hatam K, Nishiyasu T, Sigal RJ, Boulay P, Kenny GP. Superoxide and NADPH oxidase do not modulate skin blood flow in older exercising adults with and without type 2 dia-betes. Microvasc Res. 25:103886, 2019
Fujii N, McGarr GW, Hatamu K, Chandran N, Muia CM, Nishiyasu T, Boulay P, Ghassa R, Kenny GP. Heat shock protein 90 does not contribute to cutaneous vasodilatation in older adults during heat stress Microcirculation. 4:e12541, 2019
McGarr GW, Fujii N, Muia CM, Nishiyasu T, Kenny GP. Separate and combined effects of KCa and KATP channel blockade with NOS inhibition on cutaneous vasodilation and sweating in older men during heat stress. Am J Physiol Regul Integr Comp Physiol. Jul 1;317(1):R113-R120, 2019
Fujimoto T, Tsuji B, Sasaki Y, Dobashi K, Sengoku Y, Fujii N, Nishiyasu T. Low-intensity exercise delays the shivering response to core cooling. Am J Physiol Regul Integr Comp Physiol. 316(5):R535-R542, 2019
Ogawa T, Fujii N, Kurimoto Y, Nishiyasu T. Effect of hypobaria on maximal ventilation, oxygen uptake, and exercise performance during running under hypobaric normoxic conditions. Physiol Rep. Feb;7(3):e14002, 2019
Cao Y, Ichikawa Y, Sasaki Y, Ogawa T, Hiroyama T, Enomoto Y, Fujii N, Nishiyasu T. Expiratory flow limitation under moderate hypobaric hypoxia does not influence ventilatory responses during incremental running in endurance runners. Physiol Rep. (3):e13996, 2019
Meade RD, Fujii N, McGarr GW, Alexander LM, Boulay P, Sigal RJ, Kenny GP. Local arginase inhibition does not modulate cutaneous vasodilation or sweating in young and older men during exercise. J Appl Physiol. (1985), 126(4):1129-1137, 2019
Tsuji B, Hoshi Y, Honda Y, Fujii N, Sasaki Y, Cheung SS, Kondo N, Nishiyasu T. Respiratory mechanics and cerebral blood flow during heat-induced hyperventilation and its voluntary suppression in passively heated humans. Physiol Rep. 7(1):e13967, 2019
Fujii N, McGarr GW, Nishiyasu T, Sigal RJ, Boulay P, Kenny GP. Ageing attenuates muscarinic-mediated sweating differently in men and women with no effect on nicotinic-mediated sweating. Exp Dermatol. 28(8):968-971, 2019
Fujii N, Kashihara M, Kenny GP, Honda Y, Fujimoto T, Cao Y, Nishiyasu T. Carotid chemoreceptors have a limited role in mediating the hyperthermia-induced hyperventilation in exercising humans. J Appl Physiol. 126(2):305-313, 2019
2018
Fujii N, Pastore OL, McGarr GW, Meade RD, McNeely BD, Nishiyasu T, Kenny GP. Cyclooxygenase-1 and -2 modulate sweating but not cutaneous vasodilation during exercise in the heat in young men. Physiol Rep. 6(17):e13844, 2018
Fujii N, Hara H, Enomoto Y, Tanigawa S, and Nishiyasu T. Effects of work-matched supramaximal intermittent vs. submaximal constant-workload warm-up on all-out effort power output at the end of 2 minutes of maximal cycling. Eur J Sport Sci. 19(3):336-344, 2019
Amano T,Fujii N, Inoue Y, Kondo N. Cutaneous adrenergic nerve blockade attenuates sweating during incremental exercise in habitually trained men. J Appl Physiol. 1;125(4):1041-1050. 2018
Fujii N, Danquah MO, Meade RD, Nishiyasu T, and Kenny GP. The effect of exogenous activation of protease-activated receptor 2 on cutaneous vasodilatation and sweating in young males during rest and exercise in the heat. Temperature. 5(3):257-266, 2018
Fujii N, Nishiyasu T, Sigal RJ, Boulay P, McGarr GW, Kenny GP. Aging attenuates adenosine triphosphate-induced, but not muscarinic and nicotinic, cutaneous vasodilation in men. Microcirculation. 25(5):e12462, 2018
Tsuji B, Filingeri D, Honda Y, Eguchi T,Fujii N, Kondo N, Nishiyasu T. Reply to Parkes: Effect of hypocapnia on the sensitivity of hyperthermic hyperventilation and the cerebrovascular response in resting heated humans. J Appl Physiol. 124(5):1213, 2018
Fujii N, Nishiyasu T, Kenny GP. Reply to Carter and Green: HSP90: an unappreciated mediator of cutaneous vascular adaptation? J Appl Physiol. 1;124(2):522, 2018
Fujii N, Nishida Y, Ogawa T, Tanigawa S, and Nishiyasu T. Effects of work-matched moderate- and high-intensity warm-up on power output during 2-min supramaximal cycling. Biol Sport. 35(3):223-228, 2018.
Fujii N, Meade RD, Louie JC, Pegah A, Boulay P, Sigal RJ, Kenny GP. Effect of P2 receptor blockade on cutaneous vasodilation during rest and exercise in the heat in young men. Appl Physiol Nutr Metab. 43(3):312-315, 2018
Fujii N, Halili L, Nishiyasu T, Kenny GP. Voltage-gated potassium channels and NOS contribute to a sustained cutaneous vasodilation elicited by local heating in an interactive manner in young adults. Microvasc Res. 17:22-27, 2018
Fujii N, Meade RD, McNeely BD, Nishiyasu T, Sigal RJ, Kenny GP. Type 2 diabetes specifically attenuates purinergic skin vasodilatation without affecting muscarinic and nicotinic skin vasodilatation and sweating. Exp Physiol. 103(2):212-221, 2018
Meade RD, Fujii N, Poirier MP, Boulay P, Sigal RJ, Kenny GP. Oxidative stress does not influence local sweat rate during high intensity exercise. Exp Physiol. 103(2):172-178, 2018
Ichinose M, Matsumoto M, Fujii N, Yoshitake N, Nishiyasu T. Voluntary apnea during dynamic exercise activates the muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol. 314:H434-H442, 2018
Tsuji B, Filingeri D, Honda Y, Eguchi T, Fujii N, Kondo N, Nishiyasu T. Effect of hypocapnia on the sensitivity of hyperthermic hyperventilation and the cerebrovascular response in resting heated humans. J Appl Physiol. 124:225-233, 2018
2017
McNeely BD, Meade RD, Fujii N, Seely AJE, Sigal RJ, Kenny GP. Fluid replacement moderates oxidative stress- but not nitric oxide-mediated cutaneous vasodilation and sweating during prolonged exercise in the heat Am J Physiol Regul Integr Comp Physiol. 313(6):R730-R739, 2017
Amano T, Fujii N, Kenny GP, Inoue Y, Kondo N. Do nitric oxide synthase and cyclooxygenase contribute to sweating response during passive heating in endurance-trained athletes? Physiol Rep. Sep;5(17). pii: e13403, 2017
Fujii N, Murakami E, Tsuji B, Kenny GP, Nagashima K, Kondo N, Nishiyasu T. Body temperature and cold sensation during and following exercise under temperate room conditions in cold-sensitive young trained females. Physiol Rep. Nov;5(20). pii: e13465, 2017
Fujii N, Zhang SY, McNeely BD, Nishiyasu T, Kenny GP. Heat shock protein 90 contributes to cutaneous vasodilation through activating nitric oxide synthase in young male adults exercising in the heat. J Appl Physiol. 123(4):844-850, 2017
Fujii N, McNeely BD, Nishiyasu T, and Kenny GP. Intradermal administration of atrial natriuretic peptide has no effect on sweating and cutaneous vasodilator responses in young male adults. Temperature. 4: 414-419, 2017
Dobashi K, Fujii N, Watanabe K, Tsuji B, Sasaki Y, Fujimoto T, Tanigawa S, Nishiyasu T. Effect of voluntary hypocapnic hyperventilation or moderate hypoxia on metabolic and heart rate responses during high-intensity intermittent exercise. Eur J Appl Physiol. 117(8):1573-1583, 2017
Amano T, Shitara Y, Fujii N, Inoue Y, Kondo N. Evidence for β-adrenergic modulation of sweating during incremental exercise in habitually trained males. J Appl Physiol. 123(1):182-189, 2017
Fujii N, Nikawa T, Tsuji B, Kenny GP, Kondo N, Nishiyasu T. Wearing graduated compression stockings augments cutaneous vasodilation but not sweating during exercise in the heat. Physiol Rep. May;5(9). pii: e13252, 2017
Fujii N, Meade R, Akbari P, Louie JC, Alexander L, Boulay P, Sigal R, Kenny GP. No effect of ascorbate on cutaneous vasodilation and sweating in older men and those with type 2 diabetes exercising in the heat. Physiol Rep. Apr;5(7). pii: e13238, 2017-
Amano T, Fujii N, Louie JC, Meade RD, Kenny GP. Individual variations in nitric oxide synthase-dependent sweating in young and older males during exercise in the heat: role of aerobic power. Physiol Rep. Mar;5(6). pii: e13208, 2017
Fujii N, Nikawa T, Tsuji B, Kondo N, Kenny GP, Nishiyasu T. Wearing graduated compression stockings augments cutaneous vasodilation in heat-stressed resting humans. Eur J Appl Physiol. 117(5):921-929, 2017
Fujii N, McNeely BD, Nishiyasu T, Kenny GP. Prostacyclin does not affect sweating but induces skin vasodilatation to a greater extent in older versus younger women: roles of NO and KCa channels. Exp Physiol. 102(5):578-586, 2017
Louie JC, Fujii N, Meade RD, McNeely BD, Kenny GP. The roles of KCa, KATP, and KV channels in regulating cutaneous vasodilation and sweating during exercise in the heat. Am J Physiol Regul Integr Comp Physiol. 312(5):R821-R827, 2017
Haqani B, Fujii N, Kondo N, Kenny GP. The mechanisms underlying the muscle metaboreflex modulation of sweating and cutaneous blood flow in passively heated humans. Physiol Rep. 5(3). pii: e13123, 2017
Fujii N, Louie JC, McNeely BD, Amano T, Nishiyasu T, Kenny GP. Mechanisms of nicotine-induced cutaneous vasodilation and sweating in young adults: roles for KCa, KATP, and KV channels, nitric oxide, and prostanoids. Appl Physiol Nutr Metab. Mar 22:1-9, 2017
Fujii N, McNeely BD, Zhang SY, Abdellaoui YC, Danquah MO, Kenny GP. Activation of protease-activated receptor 2 mediates cutaneous vasodilatation but not sweating: roles of nitric oxide synthase and cyclo-oxygenase. Exp Physiol. 1;102(2):265-272, 2017
Fujii N, Amano T, Halili L, Louie JC, Zhang SY, McNeely BD, Kenny GP. Intradermal administration of endothelin-1 attenuates endothelium-dependent and -independent cutaneous vasodilation via Rho kinase in young adults. Am J Physiol Regul Integr Comp Physiol. 12(1):R23-R30, 2017
Fujii N, Louie JC, McNeely BD, Zhang SY, Tran MA, and Kenny GP. Nicotinic receptor activation augments muscarinic receptor-mediated eccrine sweating but not cutaneous vasodilatation in young males. Exp Physiol. 102(2):245-254, 2017
Fujii N, McNeely BD, Kenny GP. Nitric oxide synthase and cyclooxygenase modulate β-adrenergic cutaneous vasodilatation and sweating in young men. J Physiol. 594(4):1173-1184, 2017
Ichinose M, Ichinose-Kuwahara TK, Watanabe K, Kondo N, Nishiyasu T. The carotid baroreflex modifies the pressor threshold of the muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol. 313(3) 650-657, 2017
2016
Louie JC, Fujii N, Meade RD, Kenny GP. The Roles of the Na+/K+-ATPase, NKCC, and K+ Channels in Regulating Local Sweating and Cutaneous Blood Flow during Exercise in Humans in vivo. Physiol Rep. Nov;4(22). pii: e13024, 2016
Fujii N, Dervis S, Sigal RJ, Kenny GP. Type 1 diabetes modulates cyclooxygenase- and nitric oxide-dependent mechanisms governing sweating but not cutaneous vasodilation during exercising in the heat. Am J Physiol Regul Integr Comp Physiol. 311(6):R1076-R1084, 2016
Fujii N, Halili L, Singh MS, Meade RD, Kenny GP. The effect of endothelin A and B receptor blockade on cutaneous vascular and sweating responses in young males during and following exercise in the heat. J Appl Physiol. 121(6):1379-1387, 2016
Fujii N, Notley SR, Minson CT, Kenny GP. Administration of prostacyclin modulates cutaneous blood flow but not sweating in young and older males: roles for nitric oxide and calcium-activated potassium channels. J Physiol. 594(21):6419-6429, 2016
Meade RD, Louie JC, Poirier MP, McGinn R, Fujii N, Kenny GP. Exploring the mechanisms underpinning sweating: the development of a specialized ventilated capsule for use with intradermal microdialysis. Physiol Rep. Mar;4(6). pii: e12738, 2016
Fujii N, Louie JC, McNeely BD, Zhang SY, Tran MA, Kenny GP. K+ channel mechanisms underlying cholinergic cutaneous vasodilation and sweating in young humans: roles of KCa, KATP, and KV channels? Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R600-606, 2016
Louie JC,Fujii N, Meade RD, Kenny GP. The interactive contributions of Na+ /K+ -ATPase and nitric oxide synthase to sweating and cutaneous vasodilation during exercise in the heat. J Physiol. 594(12):3453-62, 2016.
Halili L, Singh MS, Fujii N, Alexander LM, Kenny GP. Endothelin-1 modulates methacholine-induced cutaneous vasodilation but not sweating in young human skin. J Physiol. 594(12):3439-52, 2016
Fujii N, Meade RD, Minson CT, Brunt VE, Boulay P, Sigal RJ, Kenny GP. Cutaneous blood flow during intradermal NO administration in young and older adults: roles for calcium-activated potassium channels and cyclooxygenase? Am J Physiol Regul Integr Comp Physiol. 310: R1081-R1087, 2016.
Fujii N, Singh MS, Halili L, Boulay P, Sigal RJ, Kenny GP. Cutaneous vascular and sweating responses to intradermal administration of prostaglandin E1 and E2 in young and older adults: a role for nitric oxide? Am J Physiol Regul Integr Comp Physiol. 310: R1064-R1072, 2016.
Fujii N, Meade RD, Alexander LM, Akbari P, Foudil-Bey I, Louie JC, Boulay P, Kenny GP. iNOS-dependent sweating and eNOS-dependent cutaneous vasodilation are evident in younger adults, but are diminished in older adults exercising in the heat. J Appl Physiol. 120: 318-327, 2016.
Amano T, Ichinose M, Inoue Y, Nishiyasu T, Koga S, Kenny GP, Kondo N. Influence of forearm muscle metaboreceptor activation on sweating and cutaneous vascular responses during dynamic exercise. Am J Physiol Regul Integr Comp Physiol. 310(11) 1332-1339, 2016
Tsuji B, Hayashi K, Kondo N, Nishiyasu T. Characteristics of hyperthermia-induced hyperventilation in humans. Temperature. 18;3(1):146-60, 2016
Tsuji B, Honda Y, Kondo N, Nishiyasu T. Diurnal variation in the control of ventilation in response to rising body temperature during exercise in the heat. Am J Physiol Regul Integr Comp Physiol. 311: R401-409, 2016.
2015
Brunt VE, Fujii N, Minson CT. Endothelial-derived hyperpolarization contributes to acetylcholine-mediated vasodilation in human skin in a dose-dependent manner. J Appl Physiol. 119: 1015-1022, 2015.
Fujii N, Halili L, Singh MS, Meade RD, Kenny GP. Intradermal administration of ATP augments methacholine-induced cutaneous vasodilation but not sweating in young males and females. Am J Physiol Regul Integr Comp Physiol. 309: R912-R919, 2015.
Fujii N, Tsuji B, Honda Y, Kondo N, Nishiyasu T. Effect of short-term exercise-heat acclimation on ventilatory and cerebral blood flow responses to passive heating at rest in humans. J Appl Physiol. 119: 435-444, 2015.
Meade RD, Fujii N, Alexander LM, Paull G, Louie JC, Flouris AD, Kenny GP. Local infusion of ascorbate augments NO-dependent cutaneous vasodilatation during intense exercise in the heat. J Physiol. 593: 4055-4065, 2015.
Fujii N, Tsuchiya S, Tsuji B, Watanabe K, Sasaki Y, Nishiyasu T. Effect of voluntary hypocapnic hyperventilation on the metabolic response during Wingate anaerobic test. Eur J Appl Physiol. 115: 1967-1974, 2015.
Delliaux S, Ichinose M, Watanabe K, Fujii N, Nishiyasu T. Cardiovascular responses to forearm muscle metaboreflex activation during hypercapnia in humans. Am J Physiol Regul Integr Comp Physiol. 309: R43-R50, 2015.
Fujii N, Paull G, McGinn R, Meade RD , Stapleton JM, Akbari P, Kenny GP. Do nitric oxide synthase and cyclooxygenase contribute to the heat loss responses in older males exercising in the heat? J Physiol. 593: 3169-3180, 2015.
Fujii N, McGinn R, Halili L, Singh MS, Kondo N, Kenny GP. Cutaneous vascular and sweating responses to intradermal administration of ATP: a role for nitric oxide synthase and cyclooxygenase? J Physiol. 593: 2515-2525, 2015.
Fujii N, Meade RD, Paull G, McGinn R, Foudil-bey I, Akbari P, Kenny GP. Can intradermal administration of angiotensin II influence human heat loss responses during whole-body heat stress? J Appl Physiol. 118: 1145-1153, 2015.
Tsuji B, Honda Y, Ikebe Y,Fujii N, Kondo N, Nishiyasu T. Voluntary suppression of hyperthermia-induced hyperventilation mitigates the reduction in cerebral blood flow velocity during exercise in the heat. Am J Physiol Regul Integr Comp Physiol. 308: R669-R679, 2015.
Amano T, Ichinose M, Inoue Y, Nishiyasu T, Koga S, Kondo N. Modulation of muscle metaboreceptor activation upon sweating and cutaneous vascular responses to rising core temperature in humans. Am J Physiol Regul Integr Comp Physiol. 308(12) 990-997, 2015
Ichinose M, Ichinose-Kuwahara T, Kondo N, Nishiyasu T. Increasing blood flow to exercising muscle attenuates systemic cardiovascular responses during dynamic exercise in humans. Am J Physiol Regul Integr Comp Physiol. 309(10) 1234-1242, 2015
2014
Stapleton JM, Fujii N, McGinn R, McDonald K, Kenny GP. Age-related differences in postsynaptic increases in sweating and skin blood flow postexercise. Physiol Rep. 2: pii: e12078, 2014.
Fujii N, McGinn R, Stapleton J, Paull G, Meade RD, Kenny GP. Evidence for cyclooxygenase-dependent sweating in young males during intermittent exercise in the heat. J Physiol. 592: 5327-5339, 2014.
McGinn R, Paull G, Meade DR,Fujii N, Kenny GP. Mechanisms underlying the postexercise baroreceptor‐mediated suppression of heat loss. Physiol Rep. 2: no. e12168, 2014.
Fujii N, Honda Y, Komura K, Tsuji B, Sugihara A, Watanabe K, Kondo N, Nishiyasu T. Effect of voluntary hypocapnic hyperventilation on the relationship between core temperature and heat loss responses in exercising humans. J Appl Physiol. 117: 1317-1324, 2014.
Fujii N, McGinn R, Paull G, Stapleton JM, Meade RD, Kenny GP. Cyclooxygenase inhibition does not alter methacholine-induced sweating. J Appl Physiol. 117: 1055-1062, 2014.
Sugihara A, Fujii N, Tsuji B, Watanabe K, Niwa T, Nishiyasu T. Hypervolemia induced by fluid ingestion at rest: effect of sodium concentration. Eur J Appl Physiol. 114: 2139-2145, 2014.
Choi PJ, Brunt VE, Fujii N, Minson CT. New approach to measure cutaneous microvascular function: an improved test of NO-mediated vasodilation by thermal hyperemia. J Appl Physiol. 117: 277-283, 2014.
Stapleton JM, Fujii N, Carter M, Kenny GP. Diminished nitric oxide-dependent sweating in older males during intermittent exercise in the heat. Exp Physiol. 99: 921-932, 2014.
McGinn R, Fujii N, Swift B, Lamarche DT, Kenny GP. Adenosine receptor inhibition attenuates the suppression of postexercise cutaneous blood flow. J Physiol. 592: 2667-2678, 2014.
Fujii N, Brunt VE, Minson CT. Tempol improves cutaneous thermal hyperemia through increasing nitric oxide bioavailability in young smokers. Am J Physiol Heart Circ Physiol. 306: H1507-H1511, 2014.
Ichinose M, Maeda S, Kondo N, Nishiyasu T. Blood pressure regulation II: what happens when one system must serve two masters-oxygen delivery and pressure regulation? Eur J Appl Physiol. 114(3) 451-456, 2014
Watanabe K, Ichinose M, Tahara R, Nishiyasu T. Individual differences in the cardiac and vascular components of the pressor response to isometric handgrip exercise in humans. Am J Physiol Heart Circ Physiol. 306(2) H1568-1575, 2014
Amano T, Ichinose M, Nishiyasu T, Inoue Y, Koga S, Miwa M, Kondo N. Sweating response to passive stretch of the calf muscle during activation of forearm muscle metaboreceptors in heated humans. Am J Physiol Regul Integr Comp Physiol. 306(10) R728-734, 2014
2013
Brunt VE, Fujii N, Minson CT. No independent, but an interactive, role of calcium-activated potassium channels in human cutaneous active vasodilation. J Appl Physiol. 115: 1290-1296, 2013.
Ichinose M, Watanabe K, Fujii N, Kondo N, Nishiyasu T. Muscle metaboreflex activation speeds the recovery of arterial blood pressure following acute hypotension in humans. Am J Physiol Heart Circ Physiol. 304: H1568-H1575, 2013.
Fujii N, Reinke MC, Brunt VE, Minson CT. Impaired acetylcholine-induced cutaneous vasodilation in young smokers: roles of nitric oxide and prostanoids. Am J Physiol Heart Circ Physiol. 304: H667-H673, 2013.
Fujii N, Ichinose M, Honda Y, Tsuji B, Watanabe K, Kondo N, Nishiyasu T. Changes in arterial blood pressure elicited by severe passive heating at rest is associated with hyperthermia-induced hyperventilation in humans. Eur J Appl Physiol. 113: 51-62, 2013.
2012
Ichinose M, Nishiyasu T. Arterial baroreflex control of muscle sympathetic nerve activity under orthostatic stress in humans. Frontiers Physiol. 3(314) 1-10, 2012
Ichinose M, Watanabe K, Fujii N, Nishiyasu T. Cardiovascular regulation during exercise-Contribution of peripheral reflexes. J Physical Fitness Sport Med. 1(3) 437-445, 2012
Fujii N, Honda Y, Delliaux S, Tsuji B, Watanabe K, Sugihara A, Kondo N, Nishiyasu T. Effect of voluntary hypocapnic hyperventilation on cutaneous circulation in resting heated humans. Am J Physiol Regul Integr Comp Physiol. 303: R975-R983, 2012.
Tsuji B, Honda Y, Fujii N, Kondo N, Nishiyasu T. Comparison of hyperthermic hyperventilation during passive heating and prolonged light and moderate exercise in the heat. J Appl Physiol. 113: 1388-1397, 2012.
Fujii N, Ogawa T, Ichinose M, Hayashi K, Nishiyasu T. Relationship between 800-m and 1500-m run times and anaerobic performance in competitive runners. Gazz Med Ital. 171: 491-501, 2012.
Fujii N, Honda Y, Ogawa T, Tsuji B, Kondo N, Koga S, Nishiyasu T. Short- term exercise-heat acclimation enhances skin vasodilation but not hyperthermic hyperpnea in humans exercising in a hot environment. Eur J Appl Physiol. 113: 51-62, 2012.
Tsuji B, Honda Y, Fujii N, Kondo N, Nishiyasu T. Effect of initial core temperature on hyperthermic hyperventilation during prolonged submaximal exercise in the heat. Am J Physiol Regul Integr Comp Physiol. 302: R94-R102, 2012.
Nishiyasu T, Tsukamoto R, Kawai K, Hayashi K, Koga S, Ichinose M. Relationships between the extent of apnea-induced bradycardia and the vascular response in the arm and leg during dynamic two-legged knee extension exercise. Am J Physiol Heart Circ Physiol. 302: H864-871, 2012
2011
Ichinose M, Delliaux S, Watanabe K,Fujii N, Nishiyasu T. Evaluation of muscle metaboreflex function through graded reduction in forearm blood flow during rhythmic handgrip exercise in humans. Am J Physiol Heart Circ Physiol. 301: H609-H616, 2011.
Amano T, Ichinose, Koga S, Inoue, Nishiyasu T, Kondo N. Sweating responses and the muscle metaboreflex under mildly hyperthermic conditions in sprinters and distance runners. J Appl Physiol. 111(2) 524-529, 2011
Hayashi K, Honda Y, Miyakawa N, Fujii N, Ichinose M, Koga S, Kondo N, and Nishiyasu T. The effect of CO2 on the ventilatory sensitivity to rising body temperature during exercise. J Appl Physiol. 110: 1334-1341, 2011.
Nishiyasu T, Fujii N, Hayashi K, Tsuji B. Point:Counterpoint: Physiological significance of hyperthermia-induced hyperpnea for selective brain cooling in humans. J Appl Physiol. 110: 1575-1580, 2011.
2010
Watanabe K, Ichinose M, Fujii N, Matsumoto M, Nishiyasu T. Individual differences in the heart rate response to activation of the muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol. 299: H1708-H1714, 2010.
Ogawa T, Calbet JA, Honda Y, Fujii N, Nishiyasu T. The effects of breathing a helium-oxygen gas mixture on maximal pulmonary ventilation and maximal oxygen consumption during exercise in acute moderate hypobaric hypoxia. Eur J Appl Physiol. 110: 853-861, 2010.
2009
Hayashi K, Honda Y, Ogawa T, Kondo N, Nishiyasu T. The cross-sectional relationships among hyperthermia-induced hyperventilation, peak oxygen consumption, and the cutaneous vasodilatory re-sponse during exercise. Eur J Appl Physiol. 107(5):527-534, 2009
2008
Ichinose M, Saito M, Kondo N, Nishiyasu T. Baroreflex and Muscle Metaboreflex: Control of Muscle Sympathetic Nerve Activity. Med Sci Sport Exer. 40(12) 2037-2045, 2008
Fujii N, Honda Y, Hayashi K, Kondo N, Nishiyasu T. Effect of hypohydration on hyperthermic hyperpnea and cutaneous vasodilation during exercise in men. J Appl Physiol. 105: 1509-1518, 2008.
Fujii N, Honda Y, Hayashi K, Kondo N, Koga S, Nishiyasu T. Effects of chemoreflexes on hyperthermic hyperventilation and cerebral blood velocity in resting heated humans. Exp Physiol. 93: 994-1001, 2008.
Ichinose M, Saito M, Fujii N, Ogawa T, Hayashi K, Kondo N, Nishiyasu T. Modulation of the control of muscle sympathetic nerve activity during incremental leg cycling. J Physiol. 586: 2753-2766, 2008.
Fujii N, Honda Y, Hayashi K, Soya H, Kondo N, Nishiyasu T. Comparison of hyperthermic hyperpnea elicited during rest and submaximal, moderate-intensity exercise. J Appl Physiol. 104: 998-1005, 2008.
2007
Nishiyasu T, Hayashida S, Kitano A, Nagashima K, Ichinose M. Effects of posture on peripheral vascular responses to lower body positive pressure. Am J Physiol Heart Circ Physiol. 293(1), 2007
Ichinose M, Koga S, Fujii N, Kondo N, Nishiyasu T. Modulation of the spontaneous beat-to-beat fluctuations in peripheral vascular resistance during activation of muscle metaboreflex. Am J Physiol Heart Circ Physiol. 293: H416-H424, 2007.
Ogawa T, Hayashi K, Ichinose M, Nishiyasu T. Relationship between resting ventilatory chemosensitivity and maximal oxygen uptake in moderate hypobaric hypoxia, J Appl Physiol. 103(4) 1221-1226, 2007
Ogawa T, Hayashi K, Ichinose M, Wada H, Nishiyasu T. Metabolic response during intermittent graded sprint running in moderate hypobaric hypoxia in competitive middle-distance runners. Eur J Appl Physiol. 99(1) 39-46, 2007
2006
Ichinose M, Saito M, Fujii N, Kondo N, Nishiyasu T. Modulation of the control of muscle sympathetic nerve activity during severe orthostatic stress. J Physiol. 576: 947-958, 2006.
Ichinose M, Saito M, Kondo N, Nishiyasu T. Time-dependent modulation of arterial baroreflex control of muscle sympathetic nerve activity during isometric exercise in humans. Am J Physiol Heart Circ Physiol. 290: H419-H426, 2006.
Nishiyasu T, Ichinose M. Comment on Point:Counterpoint”The muscle metaboreflex does/does not restore blood flow to contracting muscles”. J Appl Physiol. 100: 750, 2006
Hayashi K, Honda Y, Ogawa T, Kondo N, Nishiyasu T. Relationship between ventilatory response and body temperature during prolonged submaximal exercise. J Appl Physiol. 100: 414-20, 2006
西保 岳, 一ノ瀬 真志, 近藤 徳彦, 斉藤 満. 運動時の血流制御. 体育の科学 55: 901-906, 2006
2005
Ogawa T, Ohba K, Nabekura Y, Nagai J, Hayashi K, Wada H, Nishiyasu T. Intermittent short-term graded running performance in middle-distance runners in hypobaric hypoxia. Eur J Appl Physiol. 94(3):254-261, 2005
Kitano A, Shoemaker JK, Ichinose M, Wada H, Nishiyasu T. Comparison of cardiovascular responses between lower body negative pressure and head-up tilt. J Appl Physiol. 98: 2081-2086, 2005
Ichinose M, Nishiyasu T. Muscle metaboreflex modulates the arterial baroreflex dynamic effects on peripheral vascular conductance in humans. Am J Physiol Heart Circ Physiol. 288: H1532-H1538, 2005.
2004
Ichinose M, Saito M, Ogawa T, Hayashi K, Kondo N, Nishiyasu T. Modulation of the control of muscle sympathetic nerve activity during orthostatic stress in humans. Am J Physiol Heart Circ Physiol. 287: H2147-H2153, 2004.
Ichinose M, Saito M, Kitano A, Hayashi K, Kondo N, Nishiyasu T. Modulation of arterial baroreflex dynamic response during mild orthostatic stress in humans. J Physiol. 577: 321-330, 2004.
Ichinose M, Saito M, Wada H, Kitano A, Kondo N, Nishiyasu T. Modulation of arterial baroreflex control of muscle sympathetic nerve activity by muscle metaboreflex in humans. Am J Physiol Heart Circ Physiol. 287: H701-H707, 2004.
Hayashi K, Honda Y, Ogawa T, Wada H, Kondo N, Nishiyasu T. Effects of brief leg cooling after moderate exercise on cardiorespiratory responses to subsequent exercise in the heat. Eur J Appl Physiol. 92(4-5):414-420, 2004
2002
Ichinose M, Saito M, Wada H, Kitano A, Kondo N, Nishiyasu T. Modulation of arterial baroreflex dynamic response during muscle metaboreflex activation in humans. J Physiol. 544: 939-948, 2002.
外部資金
| 研究課題名 | 研究期間 | 研究代表者 | 研究資金 | |
| 次世代熱中症対策研究：ヒト特有の換気亢進の意義解明と新予防法開発 | 2022 — 2026 | 西保 岳 | 日本学術振興会/基盤研究(A) | 42,640,000円 |
| 高体温誘発性換気亢進反応のメカニズム解明と熱中症予防への応用 | 2017 — 2020 | 西保 岳 | 日本学術振興会/基盤研究(A) | 42,640,000円 |
| 暑熱下運動時における熱中症発症の新メカニズム検証と新予防法の提案 | 2013 — 2016 | 西保 岳 | 日本学術振興会/基盤研究(A) | 46,410,000円 |
| 競技者用バーチャルスマートトレッドミル開発 | 2013 — 2014 | 西保 岳 | 日本学術振興会/挑戦的萌芽研究 | 3,900,000円 |
| 反射性循環調節の複合作用－個人差とトレーニング効果－ | 2010 — 2012 | 西保 岳 | 日本学術振興会/基盤研究(B) | 17,810,000円 |
| 仮想（バーチャル）技術応用の新カヤックエルゴメーター開発 | 2011 — 2012 | 西保 岳 | 日本学術振興会/挑戦的萌芽研究 | 3,900,000円 |
| 反射性循環調節の複合作用とそのトレーニング効果に関する研究 | 2007 — 2009 | 西保 岳 | 日本学術振興会/基盤研究(B) | 20,150,000円 |
| データベース化に向けての３次元スポーツ心臓評価法開発 | 2005 — 2006 | 西保 岳 | 日本学術振興会/萌芽研究 | 4,300,000円 |
| 筋肉から中枢へのメッセージが循環調節やトレーニング効果に及ぼす影響 | 2004 — 2006 | 西保 岳 | 日本学術振興会/基盤研究(B) | 15,200,000円 |
| CCD画像を用いた酸素摂取量測定装置の開発 | 2002 — 2003 | 西保 岳 | 日本学術振興会/萌芽研究 | 3,300,000円 |
| 筋肉から中枢へのメッセージが運動やトレーニング効果に及ぼす影響 | 2001 — 2003 | 西保 岳 | 日本学術振興会/基盤研究(B) | 15,900,000円 |
| 多機能下半身圧力負荷装置の開発とその実用化 | 2000 — 2001 | 西保 岳 | 日本学術振興会/基盤研究(B) | 10,200,000円 |
| 低酸素条件下における末梢血管モンタリング装置ASTRIMの性能評価 | 2001 — 2001 | 西保 岳 | /企業からの受託研究 | |
| 末梢血管モニタリング装置ASTRIMの評価 | 2000 — 2000 | 西保 岳 | /企業からの受託研究 | |
| リズミカルな運動時の循環調節のメカニズム-筋機械受容器反射に着目しての新研究法- | 1997 — 1998 | 西保 岳 | 日本学術振興会/奨励研究(A)/ | |
| 筋内化学受容器を選択的に刺激する運動トレーニングが血圧調節におよぼす影響 | 1995 — 1995 | 西保 岳 | 日本学術振興会/奨励研究(A)/ | |
| 筋肉化学受容器による血圧調節に及ぼすトレーニングの影響 -縦断的トレーニング- | 1994 — 1994 | 西保 岳 | 日本学術振興会/奨励研究(A)/ | |
| 筋内化学受容器による血圧調節に及ぼす運動トレーニングの影響 | 1993 — 1993 | 西保 岳 | 日本学術振興会/奨励研究(A)/ |
| 研究課題名 | 研究期間 | 研究代表者 | 研究資金 | |
| ヒト熱放散反応におけるTRPチャネルの役割解明 -熱中症予防法確立を目指して- | 2020-04 — 2022-03 | 藤井 直人 | 日本学術振興会/基盤研究 (B) | 17,680,000円 |
| 運動による暑熱耐性向上に成長ホルモンが及ぼす影響 －熱中症予防に向けて－ | 2020-04 — 2022-03 | 藤井 直人 | 中冨健康科学振興財団/研究助成金 | 1,500,000円 |
| 熱中症予防にむけた熱放散反応の末梢メカニズムに関する研究 | 2019-04 — 2020-03 | 藤井 直人 | 日本学術振興会/卓越研究員事業 | 2,000,000円 |
| 熱中症予防にむけた熱放散反応の末梢メカニズムに関する研究 | 2018-04 — 2019-03 | 藤井 直人 | 日本学術振興会/卓越研究員事業 | 9,000,000円 |
| 熱中症予防にむけた熱放散反応の末梢メカニズムに関する研究 | 2017-11 — 2018-03 | 藤井 直人 | 日本学術振興会/卓越研究員事業 | 9,000,000円 |
| 熱中症予防を目指した熱放散反応のガラニン関連メカニズム解明 | 2019 — 2021 | 藤井 直人 | 日本学術振興会/挑戦的研究（萌芽） | 6,500,000円 |
| 熱中症予防にむけたCGRPの熱放散反応における役割解明 | 2018-12 — 2020-04 | 藤井 直人 | /上原記念生命科学財団 | 2,000,000円 |
| 熱中症予防にむけた熱放散反応の末梢メカニズム解明 | 2017 — 2019 | 藤井 直人 | 日本学術振興会/若手研究(A) | 25,610,000円 |
| 自発的過換気が高強度運動時の生理応答に及ぼす影響ー新トレーニング開発に向けてー | 2018 — 2019 | 土橋 康平 | 日本学術振興会/特別研究員奨励費 | 2,800,000円 |
学生受賞歴
最優秀賞. 第14回 筑波大学体育学学位プログラム 修士論文コンクール. 森山将大. 2022-3
APS (American Physiological Society) select. Sodium bicarbonate ingestion mitigates the heat-induced hyperventilation and reduction in cerebral blood velocity during exercise in the heat. Katagiri A, Kitadai Y, Miura A, Fukuba Y, Fujii N, Nishiyasu T, Tsuji B. 2021-12
奨励賞. 第35回運動と体温の研究会. 炭酸水素ナトリウム摂取が運動時の高体温誘発性換気亢進反応に及ぼす影響. 片桐 陽. 2021-9.
日本体力医学会国際学術交流奨励賞. 第74 回日本体力医学会大会. 土橋康平. 2019-9.
奨励賞. 第33回運動と体温の研究会. 運動間の冷気吸入が暑熱下間欠的運動時の体温および呼吸循環反応に及ぼす影響. 香嶋 啓輔, 藤本 知臣, 藤井 直人, 本田 靖, 近藤 徳彦, 西保 岳. 2019-9.
Poster 1st prize. 18th International Conference on Environmental Ergomomics. Effects of pre-exercise voluntary hypocapnic hyperventilation on cardiovascular responses to simultaneous initiation of exercise and apnea. Sakamoto Mizuki, Ichinose Masashi, Dobashi Kohei, Matsutake Ryoko, Fujii Naoto, Nishiyasu Takeshi. 2019-7.
Oral presentation 1st prize. 17th International Conference on Environmental Ergomomics. Separate effects of voluntary hyperventilation and resultant hypocapnia on metabolic and cardiovascular responses during and following supramaximal exercise. Dobashi Kohei, Fujii Naoto, Fujimoto Tomomi, Tanigawa Satoru, Ichinose Masashi, Nishiyasu Takeshi. 2017-11